Letter to the Editor: Are the CYP2D6*G and MDR1, 3435T Alleles Associated with the Risk of Ulcerative Colitis in Iranian Population?

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Ramirez Garcia Sergio Alberto; Flores Alvarado Luis Javier; Baltazar Rodriguez Luz Margarita; Cruz Diana Garcia

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2019 | Volume:22 | Issue:11 Page(s): 680-681

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Title

Letter to the Editor: Are the CYP2D6*G and MDR1, 3435T Alleles Associated with the Risk of Ulcerative Colitis in Iranian Population?

Author(s)

Ramirez Garcia Sergio Alberto | Flores Alvarado Luis Javier | Baltazar Rodriguez Luz Margarita | Cruz Diana Garcia | Issue Writer Certificate

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Abstract

Dear Editor, The paper published by Lotfi et al1 concerning the public health of the Iranian population explores three polymorphisms of genes that code for proteins that contribute to drug-related treatment of ulcerative colitis (UC): CYP2D6, NAT2 and MDR1. We analyzed the data shown in Tables 2 and 3 of both cases and control subjects, using the Epi InfoOpen program of the CDC. We found that the allele CYP2D6* 4 G variant is associated as a protective factor with the development of UC with χ 2= 3. 812, df = 1, P = 0. 05088, odds ratio (OR) = 0. 8163 (95% CI= 0. 6776– 0. 9834) (see Table 1), while the A allele was associated as a risk factor; χ 2 = 3. 812, df = 1, P = 0. 05088, OR = 1. 2251 (95% CI = 1. 017– 1. 476). While Lotfi et al have only reported the allele A as a risk factor (OR = 1. 56, P = 0. 0471), both results are important.

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APA: Copy

Ramirez Garcia, Sergio Alberto, Flores Alvarado, Luis Javier, & Baltazar Rodriguez, Luz Margarita. (2019). Letter to the Editor: Are the CYP2D6*G and MDR1, 3435T Alleles Associated with the Risk of Ulcerative Colitis in Iranian Population?. ARCHIVES OF IRANIAN MEDICINE, 22(11), 680-681. SID. https://sid.ir/paper/281889/en

Vancouver: Copy

Ramirez Garcia Sergio Alberto, Flores Alvarado Luis Javier, Baltazar Rodriguez Luz Margarita. Letter to the Editor: Are the CYP2D6*G and MDR1, 3435T Alleles Associated with the Risk of Ulcerative Colitis in Iranian Population?. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2019;22(11):680-681. Available from: https://sid.ir/paper/281889/en

IEEE: Copy

Sergio Alberto Ramirez Garcia, Luis Javier Flores Alvarado, and Luz Margarita Baltazar Rodriguez, “Letter to the Editor: Are the CYP2D6*G and MDR1, 3435T Alleles Associated with the Risk of Ulcerative Colitis in Iranian Population?,” ARCHIVES OF IRANIAN MEDICINE, vol. 22, no. 11, pp. 680–681, 2019, [Online]. Available: https://sid.ir/paper/281889/en

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