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Information Journal Paper

Title

SENSITIVITY OF SUSCEPTIBILITY-WEIGHTED IMAGING IN DETECTING SUPERPARAMAGNETIC IRON OXIDE-LABELED MESENCHYMAL STEM CELLS: A COMPARATIVE STUDY

Pages

  0-0

Abstract

 Background: Susceptibility-weighted imaging (SWI) is extremely sensitive in the detection of superparamagnetic iron oxide (SPIO) nanoparticle-labeled cells. However, no study has compared molecular imaging for stem cell detection using SWI and other MRI pulse sequences.Objectives: This study aims to assess the sensitivity of SWI in detecting SPIO nanoparticle-labeled, human bone marrow-derived mesenchymal stem cells (SPIO-hMSCs) compared with that of T2- and T2*-weighted imaging (T2WI and T2*WI, respectively) in a phantom and in vivo study in RATS.Materials and Methods: A phantom was prepared with various cell concentrations. In one normal rat, SPIO-hMSCs were implanted directly through burr holes into both caudate putamens, while in three RATS without and six RATS with photothrombotic infarction, 2.5×105/ml SPIO-hMSCs were infused into the ipsilateral internal carotid artery (ICA). T2WI, T2*WI, and SWI findings were compared for dark regions representing SPIO-hMSCs.Results: SWI and T2*WI detected 15 mL of 13 SPIO-hMSCs/mL and 15 mL of 27 SPIO-hMSCs/mL in the phantom, respectively and 3 mL of 333 SPIO-hMSCs/mL and 3 mL of 167 SPIO-hMSCs/mL in the normal rat brain (direct implantation). In the normal rat brain (ICA infusion), one of the three cases showed numerous foci of dark regions dispersed throughout the brain on T2*WI and SWI. Dark regions surrounded the infarcts in all six infracted rat brains. The dark region was most prominent on SWI, followed by T2*WI and T2WI in all six RATS (P=0.002). Implanted SPIO-hMSCs were confirmed using Prussian blue staining.Conclusions: SWI is the most sensitive in the detection of SPIO-hMSCs, with the dark regions representing SPIO-hMSCs being more prominent on SWI than on T2*WI and T2WI.

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    APA: Copy

    PARK, SERAH, KWAK, BYUNG KOOK, & JUNG, JISUNG. (2015). SENSITIVITY OF SUSCEPTIBILITY-WEIGHTED IMAGING IN DETECTING SUPERPARAMAGNETIC IRON OXIDE-LABELED MESENCHYMAL STEM CELLS: A COMPARATIVE STUDY. IRANIAN JOURNAL OF RADIOLOGY, 12(2), 0-0. SID. https://sid.ir/paper/284372/en

    Vancouver: Copy

    PARK SERAH, KWAK BYUNG KOOK, JUNG JISUNG. SENSITIVITY OF SUSCEPTIBILITY-WEIGHTED IMAGING IN DETECTING SUPERPARAMAGNETIC IRON OXIDE-LABELED MESENCHYMAL STEM CELLS: A COMPARATIVE STUDY. IRANIAN JOURNAL OF RADIOLOGY[Internet]. 2015;12(2):0-0. Available from: https://sid.ir/paper/284372/en

    IEEE: Copy

    SERAH PARK, BYUNG KOOK KWAK, and JISUNG JUNG, “SENSITIVITY OF SUSCEPTIBILITY-WEIGHTED IMAGING IN DETECTING SUPERPARAMAGNETIC IRON OXIDE-LABELED MESENCHYMAL STEM CELLS: A COMPARATIVE STUDY,” IRANIAN JOURNAL OF RADIOLOGY, vol. 12, no. 2, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/284372/en

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