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Information Journal Paper

Title

Ocular Biodistribution of 89Zr-Bevacizumab in New Zealand Rabbits Determined Using PET/MRI: A Feasibility Study (NUCLEAR MEDICINE)

Pages

  0-0

Abstract

 Background: Despite studies on positron emission tomography/magnetic resonance imaging (PET/MRI) in oncological imaging with high soft-tissue contrast resolution, PET/MRI has not been studied in ophthalmology. 89Zr-Bevacizumab, designed as a probe for PET, targets vascular endothelial growth factor, which is highly expressed in ocular angiogenesis. Intravitreal injections of bevacizumab agents have curative effects on ocular disease. Objectives: To study the ocular bioDistribution of 89Zr-Bevacizumab in New Zealand rabbits using PET/MRI. Materials and Methods: 89Zr-Bevacizumab, synthesized from conjugated bevacizumab and 89Zr-oxalate, and the purity of radiolabeled antibodies were determined using radio high-performance liquid chromatography (radio-HPLC). Instant thin-layer chromatography (ITLC) was utilized to differentiate the labeled product from aggregates and unlabeled 89Zr. 89Zr-Bevacizumab was injected 2 mm from the left limbus into the vitreous humor of six normal New Zealand white rabbits. Micro-PET was utilized for dynamic imaging from 5 minutes to 60 minutes postinjection and for static imaging at 4 hours, 24 hours, 48 hours, 120 hours, and 144 hours (10-minutes scans) postinjection. PET/MRI scans were fused using PMOD software. Results: 89Zr-Bevacizumab with a radiochemical purity of 93. 21% was monitored via PET imaging. Radioactivity levels in the Eyes plateaued approximately 5 minutes after administration of 89Zr-Bevacizumab, and the measured vitreous values decreased from 340. 52  41. 6% injected dose (ID)/g to 21. 53  3. 39%ID/g by 144 hours. The half-life of the drug in the Eye was calculated for 84. 25 hours. Conclusion: 89Zr-Bevacizumab could be monitored in animals by PET imaging, and the radiolabel exhibited high sensitivity in the vitreous body. Radioactivity levels in the Eyes plateaued approximately 5 minutes after administration. This study clearly demonstrates the bioDistribution of 89Zr-Bevacizumab.

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    APA: Copy

    Liu, Xiaoyuan, Ye, Jianqiang, ZHANG, YAN, Liu, Quan, Bai, Ruizhen, Yuan, Wenbo, Cai, Dongyan, Zheng, Xiaoyuan, Bian, Yun, Zhou, Shijun, Lv, Juan, Ding, Yongjuan, Xie, Fen, Lu, Hongwen, & Xie, Bingxue. (2019). Ocular Biodistribution of 89Zr-Bevacizumab in New Zealand Rabbits Determined Using PET/MRI: A Feasibility Study (NUCLEAR MEDICINE). IRANIAN JOURNAL OF RADIOLOGY, 16(2), 0-0. SID. https://sid.ir/paper/284494/en

    Vancouver: Copy

    Liu Xiaoyuan, Ye Jianqiang, ZHANG YAN, Liu Quan, Bai Ruizhen, Yuan Wenbo, Cai Dongyan, Zheng Xiaoyuan, Bian Yun, Zhou Shijun, Lv Juan, Ding Yongjuan, Xie Fen, Lu Hongwen, Xie Bingxue. Ocular Biodistribution of 89Zr-Bevacizumab in New Zealand Rabbits Determined Using PET/MRI: A Feasibility Study (NUCLEAR MEDICINE). IRANIAN JOURNAL OF RADIOLOGY[Internet]. 2019;16(2):0-0. Available from: https://sid.ir/paper/284494/en

    IEEE: Copy

    Xiaoyuan Liu, Jianqiang Ye, YAN ZHANG, Quan Liu, Ruizhen Bai, Wenbo Yuan, Dongyan Cai, Xiaoyuan Zheng, Yun Bian, Shijun Zhou, Juan Lv, Yongjuan Ding, Fen Xie, Hongwen Lu, and Bingxue Xie, “Ocular Biodistribution of 89Zr-Bevacizumab in New Zealand Rabbits Determined Using PET/MRI: A Feasibility Study (NUCLEAR MEDICINE),” IRANIAN JOURNAL OF RADIOLOGY, vol. 16, no. 2, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/284494/en

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