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Information Journal Paper

Title

HER2-Positive Breast Cancer: Tumor-to-Liver SUV Ratio is the Best Parameter for Detection in F-18 FDG-PET/CT

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  0-0

Abstract

 Background: Fluorine-18 fluorodeoxyglucose (F-18 FDG)-Positron Emission Tomography/computed tomography (PET/CT) is widely used in most malignancy workups, including detection, differential diagnosis, staging and/or restaging, therapeutic decisionmaking, follow-up, and prognosis. Objectives: The aim of this study was to evaluate the usefulness of F-18 FDG-PET/CT for predicting Breast Cancer molecular subtypes. Patients and Methods: Sixty-six patients with pathologically proven invasive breast carcinoma (IBC) underwent F-18 FDG-PET/CT imaging for tumor staging. The maximum standardized uptake value (tumor SUVmax) of the IBC and mean SUVs of the liver and spleen (liver and spleen SUVmean) were measured. Molecular subtype was determined according to genomic analysis. The tumor SUVmax, tumor-to-liver SUV ratio, and tumor-to-spleen SUV ratio were correlated with molecular subtype data. Results: Logistic analysis demonstrated that only the tumor-to-liver SUV ratio was a significant parameter for human epidermal growth factor type 2 (HER2)-positive subtype identification (P = 0. 0049). The sensitivity, specificity, and area under the receiveroperating-characteristic curve (AUC) of this parameter for HER2-positive subtype detection were 83%, 79%, and 0. 87, respectively. Conclusion: The tumor-to-liver SUV ratio appears to be useful for HER2-positive subtype identification, thus indicating the potential use of F-18 FDG-PET/CT as an imaging biomarker that could facilitate the clinical management of patients with Breast Cancer.

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    APA: Copy

    Noda, Yoshifumi, Goshima, Satoshi, Kawada, Hiroshi, Kawai, Nobuyuki, Koyasu, Hiromi, & Matsuo, Masayuki. (2017). HER2-Positive Breast Cancer: Tumor-to-Liver SUV Ratio is the Best Parameter for Detection in F-18 FDG-PET/CT. IRANIAN JOURNAL OF RADIOLOGY, 14(3), 0-0. SID. https://sid.ir/paper/284641/en

    Vancouver: Copy

    Noda Yoshifumi, Goshima Satoshi, Kawada Hiroshi, Kawai Nobuyuki, Koyasu Hiromi, Matsuo Masayuki. HER2-Positive Breast Cancer: Tumor-to-Liver SUV Ratio is the Best Parameter for Detection in F-18 FDG-PET/CT. IRANIAN JOURNAL OF RADIOLOGY[Internet]. 2017;14(3):0-0. Available from: https://sid.ir/paper/284641/en

    IEEE: Copy

    Yoshifumi Noda, Satoshi Goshima, Hiroshi Kawada, Nobuyuki Kawai, Hiromi Koyasu, and Masayuki Matsuo, “HER2-Positive Breast Cancer: Tumor-to-Liver SUV Ratio is the Best Parameter for Detection in F-18 FDG-PET/CT,” IRANIAN JOURNAL OF RADIOLOGY, vol. 14, no. 3, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/284641/en

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