Lower Gray Matter Density in the Anterior Cingulate Cortex and Putamen Can Be Traceable in Chronic Heroin Dependents After Over Three Months of Successful Abstinence

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Keihani Ahmadreza; EKHTIARI HAMED; BATOULI SEYED AMIR HOSSEIN; SHAHBABAIE ALIREZA; Sadighi Nahid; Mirmohammad Mahdieh; OGHABIAN MOHAMMAD ALI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Radiology Year:2017 | Volume:14 | Issue:3 Page(s): 0-0

Download Full-Text

View:

208

Download:

102

Cites:

Information Journal Paper

Title

Lower Gray Matter Density in the Anterior Cingulate Cortex and Putamen Can Be Traceable in Chronic Heroin Dependents After Over Three Months of Successful Abstinence

Author(s)

Keywords

Addiction

Heroin

Structural Magnetic Resonance Imaging (sMRI)

Gray Matter Density (GMD)

Voxel-Basedmorphometry (VBM)

Abstract

Background: In recent years, a few studies have addressed the effect of chronic Heroin useonbrain structure with respect to volume and shape; however, the literature in this field is sparse and further studies are necessary to generate robust replications. Objectives: In this study, we intended to assess gray matter density (GMD) differences between successfully abstinent Heroin dependents and healthy subjects. Indirect evidences for the causal role of drug use in the GMD differences are also targeted here by testing the hypothesis on the correlation between GMD differences and duration of drug use. Patients and Methods: Using structural magnetic resonance imaging (MRI) and voxel-based morphology (VBM) technique, changes in gray matter volume and density were evaluated in 18 abstinent Heroin dependents and 20 age-, education-and gendermatchedhealthy subjects. Heroin dependents were all male, andat least 3monthssuccessfully abstinent(meanabstinence duration = 9. 2 5. 2 months). Results: DecreasedGMDin the right anterior cingulate cortex and bilateral putamen were found in abstinent Heroin dependents in comparison to controls, corrected for multiple comparisons (P < 0. 05). Also, partial correlation analysis, corrected for age, showed negative correlations between total intracranial volume (TIV) and total GMD (r =-0. 61 and-0. 44, respectively) with the duration of opiate usage in Heroin dependents. GMD in the right putamen also had negative correlation with the duration of drug abuse (r =-0. 49) and a weak negative correlation was observed between left putamen density and duration of drug abuse (r =-0. 42). Examination of the negative correlation between the duration of drug abuse before the age of 25 years and total GMD, while controlling for age, showed weak negative results (r =-0. 44). Conclusion: Specific structural changeswere noticeable in prefrontalandstriatal areas in the Heroindependents even after a period of successful abstinence. Our results onthe interaction between duration of drug use andsomeof these structural changes provides preliminary ideas for reciprocal cause and effect roles for brain structural changes and Heroin abuse. These findings might also imply that brain structures are unable to return to normal state and cannot recover spontaneously even after months of abstinence. This evidence reminds us of the importance of neurorehabilitation interventions after termination of drug use.

Cites

Some Points to Consider in a Task-Based fMRI Study: A Guideline for Beginners

References

No record.

Cite

APA: Copy

Keihani, Ahmadreza, EKHTIARI, HAMED, BATOULI, SEYED AMIR HOSSEIN, SHAHBABAIE, ALIREZA, Sadighi, Nahid, Mirmohammad, Mahdieh, & OGHABIAN, MOHAMMAD ALI. (2017). Lower Gray Matter Density in the Anterior Cingulate Cortex and Putamen Can Be Traceable in Chronic Heroin Dependents After Over Three Months of Successful Abstinence. IRANIAN JOURNAL OF RADIOLOGY, 14(3), 0-0. SID. https://sid.ir/paper/284642/en

Vancouver: Copy

Keihani Ahmadreza, EKHTIARI HAMED, BATOULI SEYED AMIR HOSSEIN, SHAHBABAIE ALIREZA, Sadighi Nahid, Mirmohammad Mahdieh, OGHABIAN MOHAMMAD ALI. Lower Gray Matter Density in the Anterior Cingulate Cortex and Putamen Can Be Traceable in Chronic Heroin Dependents After Over Three Months of Successful Abstinence. IRANIAN JOURNAL OF RADIOLOGY[Internet]. 2017;14(3):0-0. Available from: https://sid.ir/paper/284642/en

IEEE: Copy

Ahmadreza Keihani, HAMED EKHTIARI, SEYED AMIR HOSSEIN BATOULI, ALIREZA SHAHBABAIE, Nahid Sadighi, Mahdieh Mirmohammad, and MOHAMMAD ALI OGHABIAN, “Lower Gray Matter Density in the Anterior Cingulate Cortex and Putamen Can Be Traceable in Chronic Heroin Dependents After Over Three Months of Successful Abstinence,” IRANIAN JOURNAL OF RADIOLOGY, vol. 14, no. 3, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/284642/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops