PREPARATION, DISTRIBUTION, STABILITY AND TUMOR IMAGING PROPERTIES OF [62ZN] BLEOMYCIN COMPLEX IN NORMAL AND TUMOR-BEARING MICE

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JALILIAN A.R.; FATEH B.; GHERGHEREHCHI M.; KARIMIAN A.; MATLLOOBI M.; MORADKHANI S.; KAMALI DEHGHAN M.

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Journal Paper

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Journal: International Journal of Radiation Research Year:2003 | Volume:1 | Issue:1 Page(s): 37-44

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Title

PREPARATION, DISTRIBUTION, STABILITY AND TUMOR IMAGING PROPERTIES OF [62ZN] BLEOMYCIN COMPLEX IN NORMAL AND TUMOR-BEARING MICE

Author(s)

Keywords

PET

PHARMACOKINETIC

BIODISTRIBUTION

ZINC-62

BLEOMYCIN

Abstract

Backgrounds: BLEOMYCIN (BLM) has been labeled with radioisotopes and widely used in therapy and diagnosis. In this study BLM was labeled with [62Zn] zinc chloride for oncologic PET studies. Materials and methods: The complex was obtained at the pH=2 in normal saline at 90 ° C in 60 min. Radio-TLC showed an overall radiochemical yield of 95-97% (radiochemical purity > 97%). Stability of complex was checked in vitro in mice and human plasma/urine. Results: Preliminary in vivo studies performed to determine complex stability and distribution of [62Zn] BLM in normal and fibrosarcoma-bearing mice. [62Zn] BLM accumulated significantly in induced fibrosarcoma tumors in mice according to bio-distribution/imaging studies. Conclusion: [62Zn] BLM can be used in PET oncology studies due to its suitable physico-chemical properties as a diagnostic complex in vitro and in vivo. Further studies should be performed for evaluation of the complex behavior in higher animals

Cites

PREPARATION, BIODISTRIBUTION AND STABILITY OF [65ZN]BLEOMYCIN COMPLEX

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APA: Copy

JALILIAN, A.R., FATEH, B., GHERGHEREHCHI, M., KARIMIAN, A., MATLLOOBI, M., MORADKHANI, S., & KAMALI DEHGHAN, M.. (2003). PREPARATION, DISTRIBUTION, STABILITY AND TUMOR IMAGING PROPERTIES OF [62ZN] BLEOMYCIN COMPLEX IN NORMAL AND TUMOR-BEARING MICE. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 1(1), 37-44. SID. https://sid.ir/paper/286280/en

Vancouver: Copy

JALILIAN A.R., FATEH B., GHERGHEREHCHI M., KARIMIAN A., MATLLOOBI M., MORADKHANI S., KAMALI DEHGHAN M.. PREPARATION, DISTRIBUTION, STABILITY AND TUMOR IMAGING PROPERTIES OF [62ZN] BLEOMYCIN COMPLEX IN NORMAL AND TUMOR-BEARING MICE. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2003;1(1):37-44. Available from: https://sid.ir/paper/286280/en

IEEE: Copy

A.R. JALILIAN, B. FATEH, M. GHERGHEREHCHI, A. KARIMIAN, M. MATLLOOBI, S. MORADKHANI, and M. KAMALI DEHGHAN, “PREPARATION, DISTRIBUTION, STABILITY AND TUMOR IMAGING PROPERTIES OF [62ZN] BLEOMYCIN COMPLEX IN NORMAL AND TUMOR-BEARING MICE,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 1, no. 1, pp. 37–44, 2003, [Online]. Available: https://sid.ir/paper/286280/en

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