THE ROLE OF RAD51 PROTEIN IN RADIORESISTANCE OF SPHEROID MODEL OF DU145 PROSTATE CARCINOMA CELL LINE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAGHIZADEH M.; KHOUEI S.; NIKOUFAR A.R.; GHAMSARI L.; GOLIAEI B.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Radiation Research Year:2009 | Volume:7 | Issue:1 Page(s): 19-25

Download Full-Text

View:

298

Download:

167

Cites:

Information Journal Paper

Title

THE ROLE OF RAD51 PROTEIN IN RADIORESISTANCE OF SPHEROID MODEL OF DU145 PROSTATE CARCINOMA CELL LINE

Author(s)

Keywords

MULTICELLULAR SPHEROID

RADIORESISTANCE

DU145 PROSTATE CARCINOMA CELL LINE

RAD51

Abstract

Background: RAD51 is a protein with critical role in double strand break repair. Down-regulation of this protein has a significant effect in radiosensitivity of some cell lines like prostate carcinoma. Compared to monolayer cell culture model, the spheroids are more resistant to radiation. The aim of the current study was to determine the RAD51 protein level in DU145 spheroids, and monolayer cells before and after exposure to gamma irradiation. Materials and Methods: In the present study, western blot was used to determine the level of RAD51 protein in DU145 cell line grown as monolayer and spheroid. Results: Western blot analysis showed that in the spheroid cells, RAD51 had an elevated level before and after radiation in comparison with monolayer cells. Higher doses of radiation induced elevated expression of RAD51 protein in both culture models. The level of at protein after exposure to gamma rays had been timedependent. Conclusion: RAD51 might act as a mediator of radiation resistance in tumor cells. Repression of RAD51 activity ould be a prominent strategy to overcome radiation resistance of tumors.

Cites

No record.

References

No record.

Cite

APA: Copy

TAGHIZADEH, M., KHOUEI, S., NIKOUFAR, A.R., GHAMSARI, L., & GOLIAEI, B.. (2009). THE ROLE OF RAD51 PROTEIN IN RADIORESISTANCE OF SPHEROID MODEL OF DU145 PROSTATE CARCINOMA CELL LINE. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 7(1), 19-25. SID. https://sid.ir/paper/286514/en

Vancouver: Copy

TAGHIZADEH M., KHOUEI S., NIKOUFAR A.R., GHAMSARI L., GOLIAEI B.. THE ROLE OF RAD51 PROTEIN IN RADIORESISTANCE OF SPHEROID MODEL OF DU145 PROSTATE CARCINOMA CELL LINE. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2009;7(1):19-25. Available from: https://sid.ir/paper/286514/en

IEEE: Copy

M. TAGHIZADEH, S. KHOUEI, A.R. NIKOUFAR, L. GHAMSARI, and B. GOLIAEI, “THE ROLE OF RAD51 PROTEIN IN RADIORESISTANCE OF SPHEROID MODEL OF DU145 PROSTATE CARCINOMA CELL LINE,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 7, no. 1, pp. 19–25, 2009, [Online]. Available: https://sid.ir/paper/286514/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops