SYNTHESIS AND BIODISTRIBUTION STUDY OF A CHLOROTOXIN DERIVATIVE PEPTIDE LABELED WITH 131- IODINE FOR TUMOR THERAPY

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SHIRMARDI S.P.; SHAMSAEI M.; GANDOMKAR M.; GHANNADI MARAGHEH M.

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Journal: International Journal of Radiation Research Year:2011 | Volume:8 | Issue:4 Page(s): 243-248

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Title

SYNTHESIS AND BIODISTRIBUTION STUDY OF A CHLOROTOXIN DERIVATIVE PEPTIDE LABELED WITH 131- IODINE FOR TUMOR THERAPY

Author(s)

SHIRMARDI S.P. | SHAMSAEI M. | GANDOMKAR M. | GHANNADI MARAGHEH M. | Issue Writer Certificate

Keywords

CANCER

PEPTIDE

131I

LABELING

CHLOROTOXIN

Abstract

Background: CHLOROTOXIN is a 36-amino acid PEPTIDE found in the venom of the Leiurus quinquestriatus which blocks small-conductance chloride channels. CHLOROTOXIN binds preferentially to glioma cells that allow development of new methods for the treatment and diagnosis of several types of CANCER. Thus CHLOROTOXIN derivative was labeled with 131I for further investigation.Materials and Methods: A CHLOROTOXIN derivative was synthesized on a solid phase using a standard Fmoc strategy. LABELING with iodine-131 was performed through chloramine-T method and radiochemical analysis involved sephadex G-25 and HPLC methods. The stability of radiopeptide was checked in the presence of PBS and human serum at 37oC up to 24 h. The biodistribution was studied in mice.Results: The chemical purity of synthesized PEPTIDE as assessed by analytical RP-HPLC was 95%. LABELING of PEPTIDE resulted in a radiochemical yield of 80% with radiochemical purity of>95% with specific activity of 0.740 GBq/μmol. Result of in vitro studies demonstrated acceptable stability of compound in human serum and PBS solution. Biodistribution data showed moderate blood clearance, with concentration of radioactivity in the kidneys, liver, intestine and stomach.Conclusion: Results indicates that the labeled CHLOROTOXIN derivative might be useful in determining tumor extent and also, tumor therapy of gliomas or possibily other CANCERs.

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APA: Copy

SHIRMARDI, S.P., SHAMSAEI, M., GANDOMKAR, M., & GHANNADI MARAGHEH, M.. (2011). SYNTHESIS AND BIODISTRIBUTION STUDY OF A CHLOROTOXIN DERIVATIVE PEPTIDE LABELED WITH 131- IODINE FOR TUMOR THERAPY. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 8(4), 243-248. SID. https://sid.ir/paper/286547/en

Vancouver: Copy

SHIRMARDI S.P., SHAMSAEI M., GANDOMKAR M., GHANNADI MARAGHEH M.. SYNTHESIS AND BIODISTRIBUTION STUDY OF A CHLOROTOXIN DERIVATIVE PEPTIDE LABELED WITH 131- IODINE FOR TUMOR THERAPY. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2011;8(4):243-248. Available from: https://sid.ir/paper/286547/en

IEEE: Copy

S.P. SHIRMARDI, M. SHAMSAEI, M. GANDOMKAR, and M. GHANNADI MARAGHEH, “SYNTHESIS AND BIODISTRIBUTION STUDY OF A CHLOROTOXIN DERIVATIVE PEPTIDE LABELED WITH 131- IODINE FOR TUMOR THERAPY,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 8, no. 4, pp. 243–248, 2011, [Online]. Available: https://sid.ir/paper/286547/en

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