مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

RADIO-PROTECTIVE EFFECT OF HYDROGEN RICH WATER COMBINED WITH AMIFOSTINE IN MICE

Pages

  113-118

Abstract

 Background: Hydrogen has been demonstrated can selecvely reduce the hydroxyl, which is the main cause of ionizing radiaon-induced damage.Amifosne (AM) is the only radioprotecve drug approved by the U.S. Food and Drug Administraon for use in radiotherapy. The purpose of the present study was to invesgate the combined radio-protecve effect of HYDROGEN RICH WATER (HRW) and AM.Materials and Methods: Male ICR MICE were treated intragastrically with HRW or/and intraperitoneally with AM 30 minutes prior to 9.0 Gy whole body irradiaon from a60Co source (dose rate 0.96Gy/min). Then the survival rate for 30 days, the hematological parameters, the Clinical chemistry parameters and the bone marrow nucleated cells were examined.Results: We found that the MICE treated with HRW and AM before irradiaon could increase the 30-day survival rate and improve the body weight be2er than the HRW or AM treatment alone group and irradiaon alone group. Hematological test and Clinical chemistry assays also showed the same results that HRW combined AM could be2er improve the recovery of hemopoiec system and alleviate the detrimental effects of radiaon.Conclusion: The results indicate that the combined applicaon of HRW and AM may be a be2er method for radiaon therapy.

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    • Cite

    APA: Copy

    QIN, X., YIN, J., LI, J., AN, Q., WEN, JIANHUA, & NIU, QIAO. (). . , (), -. SID. https://sid.ir/paper/286709/en

    Vancouver: Copy

    QIN X., YIN J., LI J., AN Q., WEN JIANHUA, NIU QIAO. . [Internet]. ;():-. Available from: https://sid.ir/paper/286709/en

    IEEE: Copy

    X. QIN, J. YIN, J. LI, Q. AN, JIANHUA WEN, and QIAO NIU, “,” , vol. , no. , pp. –, , [Online]. Available: https://sid.ir/paper/286709/en

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