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Information Journal Paper

Title

Antioxidant and antimutagenic properties of calcium sennosides in γ-Irradiated human blood cultures

Pages

  323-332

Abstract

 Background: Calcium sennosides are the main ac ve metabolites of sennas, which have a powerful interest to phytochemical and pharmacological research, due to their brilliant medicinal values. It is well known in folk medicine for their laxa ve and purga ve uses. Materials and Methods: This experiment aimed to assess cytogene c (micronucleus assay and chromosomal aberra on study) and biochemical effects of Calcium sennosides at a working dose (24 or 48 mg/ ml) on suppressing radia on hazards in human blood cultures. Biochemical inves ga ons include superoxide dismutase (SOD), catalase (CAT), tumor necrosis factor-α (TNF-α ), interleukin-8 (IL-8), cyclooxygenase-2 (COX-2) and lactate dehydrogenase (LDH) levels. The treatment periods were 48 and 72 hrs post-irradia on at a dose of 3 Gy. Triple blood cultures for each blood sample were set up. Results: Ionizing radia on exposure induced significant increase in micronuclei (MN) frequencies in both mono-and bi-nucleated cells, and all types of chromosome aberra ons, beside significant decrease in SOD and CAT ac vi es. While TNF-α , IL-8, COX-2 and LDH levels were significantly increased a: er irradia on. Treatment with Calcium sennosides exhibited decreased of micronuclei and chromosome aberra on numbers and enhancement in the level of SOD and CAT ac vi es. In addi on, a significant ameliora on in IL-8, TNF-α , COX-2 levels and LDH ac vity were scored. Conclusion: Present results revealed the an mutagenic and the an-inflammatory effects of sennosides against oxida ve stress induced by γ-irradia on.

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    Cite

    APA: Copy

    AHMED, M.M., Said, z.s., Montaser, s.a., & El Tawil, G.A.. (2018). Antioxidant and antimutagenic properties of calcium sennosides in γ-Irradiated human blood cultures. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 16(3), 323-332. SID. https://sid.ir/paper/286745/en

    Vancouver: Copy

    AHMED M.M., Said z.s., Montaser s.a., El Tawil G.A.. Antioxidant and antimutagenic properties of calcium sennosides in γ-Irradiated human blood cultures. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2018;16(3):323-332. Available from: https://sid.ir/paper/286745/en

    IEEE: Copy

    M.M. AHMED, z.s. Said, s.a. Montaser, and G.A. El Tawil, “Antioxidant and antimutagenic properties of calcium sennosides in γ-Irradiated human blood cultures,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 16, no. 3, pp. 323–332, 2018, [Online]. Available: https://sid.ir/paper/286745/en

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