Analysis of microRNAs expression changes in human breast cancer cell lines following exposure to ionizing radiation

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DEHGHAN KOUHESTANI S.; FOROUZANDEH M.; AGHILI M.

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Journal Paper

Paper Information

Journal: International Journal of Radiation Research Year:2018 | Volume:16 | Issue:3 Page(s): 383-388

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Information Journal Paper

Title

Analysis of microRNAs expression changes in human breast cancer cell lines following exposure to ionizing radiation

Author(s)

DEHGHAN KOUHESTANI S. | FOROUZANDEH M. | AGHILI M. | Issue Writer Certificate

Keywords

miR-34a

miR-21

let-7i

ionizing radiation

breast cancer

Abstract

Background: The expression altera ons of specific miRNAs were analysed in response to gamma-irradia on in two breast cancer cell lines MCF-7 and MDA-MB-231 with low and high BCSCs content to design probable strategies for sensi zing breast cancer stem-like cells MDA-MB-231 to radia on. Materials and Methods: The expression levels of hsa-miR-34a, hsa-let-7i and hsa-miR-21 were assessed by QRT-PCR in MCF-7 and MDA-MB-231 breast cancer cells at three me points a/er gamma irradia on using three different doses. Results: The results showed that the over-expression of hsa-miR-34a in MCF-7 cells was much more significant than MDA-MB-231 cells. Furthermore, there was a considerable overexpression of hsa-miR-21 in MDA-MB-231 cells following exposure to ionizing radia on (IR). The hsa-let-7i expression changes were different, depending on radia on dose, me post irradia on and cell type. Conclusion: According to the results, we may be able to sensi ze stem-like MDA-MB-231 breast cancer cells to radia on by increasing miR-34a and decreasing miR-21 expression levels simultaneously.

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APA: Copy

DEHGHAN KOUHESTANI, S., FOROUZANDEH, M., & AGHILI, M.. (2018). Analysis of microRNAs expression changes in human breast cancer cell lines following exposure to ionizing radiation. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 16(3), 383-388. SID. https://sid.ir/paper/286747/en

Vancouver: Copy

DEHGHAN KOUHESTANI S., FOROUZANDEH M., AGHILI M.. Analysis of microRNAs expression changes in human breast cancer cell lines following exposure to ionizing radiation. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2018;16(3):383-388. Available from: https://sid.ir/paper/286747/en

IEEE: Copy

S. DEHGHAN KOUHESTANI, M. FOROUZANDEH, and M. AGHILI, “Analysis of microRNAs expression changes in human breast cancer cell lines following exposure to ionizing radiation,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 16, no. 3, pp. 383–388, 2018, [Online]. Available: https://sid.ir/paper/286747/en

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