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Information Journal Paper

Title

The effects of zinc in the gastrointestinal system as a radioprotective agent

Pages

  333-339

Abstract

 Background: Radioiodine I131 therapy (RAI) is an efficient method to decrease the func oning of very ac ve thyroid  ssues and to ablate the remnant thyroidal  ssue a er surgery and its metastases in differen ated thyroid carcinomas. Several cytoprotec ve, an-oxidant or radioprotec ve mediators have been used in trials for RAI-induced damage in other organ systems. The hypothesis of this study was that zinc would ameliorate RAI-induced histopathological parameters in the rat gastrointes nal system. Materials and Methods: A total of 30 female Wistar albino rats were separated into 3 groups of 10. First group received only 0. 003 mCi/ g of I131, second group received 0. 003 mCi/g of I131 and 0. 01 mg/g of zinc and the control group (Sham Group) were given neither I131 nor zinc. zinc was started via gastric gavage two days before I131 administra on and con nued for five days a er RAI. At 24 hours a er the last dosage of zinc, all the animals were sacrificed and the gastrointes nal  ssues, including stomach, duodenum, ileum and colon were removed for histopathological examina on. Results: All the histopathological parameters were diminished in the I131-zinc group compared to the I131 group. The histopathological differences were sta s cally significant in respect of inflamma on and fibrosis between the I131-zinc group and the I131 group in all the evaluated gastrointes nal organs (p< 0. 05). Conclusion: The co-administra on of zinc was observed to significantly prevent RAI-induced histopathological altera ons in rats.

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    Cite

    APA: Copy

    Akbulut, a., Sadic, m., Yumusak, n., Aydinbelge, f.n., Koca, g., & KORKMAZ, M.. (2018). The effects of zinc in the gastrointestinal system as a radioprotective agent. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 16(3), 333-339. SID. https://sid.ir/paper/286751/en

    Vancouver: Copy

    Akbulut a., Sadic m., Yumusak n., Aydinbelge f.n., Koca g., KORKMAZ M.. The effects of zinc in the gastrointestinal system as a radioprotective agent. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2018;16(3):333-339. Available from: https://sid.ir/paper/286751/en

    IEEE: Copy

    a. Akbulut, m. Sadic, n. Yumusak, f.n. Aydinbelge, g. Koca, and M. KORKMAZ, “The effects of zinc in the gastrointestinal system as a radioprotective agent,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 16, no. 3, pp. 333–339, 2018, [Online]. Available: https://sid.ir/paper/286751/en

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