FORMULATION AND CLINICAL EVALUATION OF POVIDONE-IODINE OPHTHALMIC DROP

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BAHRI NAJAFI R.; MOHAMMADI SAMANI S.; PISHVA N.; MOHEYMANI F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2003 | Volume:2 | Issue:3 Page(s): 157-160

Download Full-Text

View:

695

Download:

452

Cites:

Information Journal Paper

Title

FORMULATION AND CLINICAL EVALUATION OF POVIDONE-IODINE OPHTHALMIC DROP

Author(s)

BAHRI NAJAFI R. | MOHAMMADI SAMANI S. | PISHVA N. | MOHEYMANI F. | Issue Writer Certificate

Keywords

OPHTHALMIA NEONATORUM

POVIDONE-IODINE

OPHTHALMIC SOLUTION

CONJUNCTIVITIS

Abstract

OPHTHALMIA NEONATORUM is generally defined as CONJUNCTIVITIS occurring within one month of life. The sources of this infection are environmental organisms or the organisms colonized in the birth canal. Untreated infection can cause blindness, especially if the corresponding organisms areNeisseria gonorrhoeae, or Chlamydia trachomatis.Povidone-iodine OPHTHALMIC SOLUTION is an effective antibacterial agent with broad antibacterial and antiviral activity to which no bacterial resistance has been known. It is less expensive and less toxic than the agents currently used to prevent neonatal CONJUNCTIVITIS. It turns the conjunctiva brown for a few minutes, a characteristic that can serve as an indicator of being properly applied. Because this preparation is not available in Iran, its formulation can be valuable.In this study, the POVIDONE-IODINE OPHTHALMIC SOLUTION was prepared in concentration of 2.5%, and then required control parameters such as pH, self-preservation effect, tonicity, sterility, and chemical stability were studied. In this clinical study, one drop of POVIDONE-IODINE OPHTHALMIC SOLUTION was instilled in each eye of 475 neonates within 30 minutes of birth.This study demonstrated that POVIDONE-IODINE in concentration of 2.5% is self-preservative against microbial contamination. The pH of solution was adjusted about 5 near to the pH of tear using sodium hydroxide 0.1 N and citric acid 0.5%, because in this pH POVIDONE-IODINE was more stable. Tonicity was measured according to an in vitro hemolytic method. POVIDONE-IODINE 2.5% solution was packaged in amber color bottles, and after ensuring from its sterility, it was used in clinical study. Among the population studied, eye discharge was observed in 2.94 percent in comparison to the control group in which eye discharge was observed in 10.9 percent.In conclusion because of availability, low cast, and good clinical results, a 2.5% OPHTHALMIC SOLUTION of POVIDONE-IODINE is desirable to use as a prophylactic agent against OPHTHALMIA NEONATORUM.

Cites

No record.

References

No record.

Cite

APA: Copy

BAHRI NAJAFI, R., MOHAMMADI SAMANI, S., PISHVA, N., & MOHEYMANI, F.. (2003). FORMULATION AND CLINICAL EVALUATION OF POVIDONE-IODINE OPHTHALMIC DROP. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 2(3), 157-160. SID. https://sid.ir/paper/286966/en

Vancouver: Copy

BAHRI NAJAFI R., MOHAMMADI SAMANI S., PISHVA N., MOHEYMANI F.. FORMULATION AND CLINICAL EVALUATION OF POVIDONE-IODINE OPHTHALMIC DROP. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2003;2(3):157-160. Available from: https://sid.ir/paper/286966/en

IEEE: Copy

R. BAHRI NAJAFI, S. MOHAMMADI SAMANI, N. PISHVA, and F. MOHEYMANI, “FORMULATION AND CLINICAL EVALUATION OF POVIDONE-IODINE OPHTHALMIC DROP,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 2, no. 3, pp. 157–160, 2003, [Online]. Available: https://sid.ir/paper/286966/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops