THE EFFECT OF ORAL ADMINISTRATION OF L-TYROSINE, FOLIC ACID AND PYRIDOXINE ON PERPHENAZINE INDUCED CATATONIA IN RAT

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ARZI A.; REZAEI MOHSEN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2003 | Volume:2 | Issue:3 Page(s): 167-171

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Title

THE EFFECT OF ORAL ADMINISTRATION OF L-TYROSINE, FOLIC ACID AND PYRIDOXINE ON PERPHENAZINE INDUCED CATATONIA IN RAT

Author(s)

ARZI A. | REZAEI MOHSEN | Issue Writer Certificate

Keywords

L-TYROSINE

FOLIC ACID

PYRIDOXINE

PARKINSON S DISEASE

RAT

Abstract

L-TYROSINE, B6 and FOLIC ACID are involved in biosynthesis of DOPA and consequently dopamine. The aim of this study was to investigate the antiparkinsonian effect of these agents in perphenazine-induced catatonia in RATs. Murprogo method or scored muscular rigidity, which is induced by a phenothiazine, was used to evaluate the antiparkinsonian effect of these agents. A significant decrease in muscular rigidity was observed in groups that received L-TYROSINE. However, groups which had received vitamin (s) only showed no significant decrease in muscular rigidity as compared with the control group. On the other hand, the group receiving FOLIC ACID plus L-TYROSINE showed a lower degree of muscular rigidity in comparison with the other groups.In conclusion, L-TYROSINE has been found to be effective in improving perphenazine-induced muscular rigidity. Furthermore, when used in combination with FOLIC ACID, L-TYROSINE could be found advantageous in the early stages of Parkinson’s disease.

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APA: Copy

ARZI, A., & REZAEI, MOHSEN. (2003). THE EFFECT OF ORAL ADMINISTRATION OF L-TYROSINE, FOLIC ACID AND PYRIDOXINE ON PERPHENAZINE INDUCED CATATONIA IN RAT. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 2(3), 167-171. SID. https://sid.ir/paper/286967/en

Vancouver: Copy

ARZI A., REZAEI MOHSEN. THE EFFECT OF ORAL ADMINISTRATION OF L-TYROSINE, FOLIC ACID AND PYRIDOXINE ON PERPHENAZINE INDUCED CATATONIA IN RAT. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2003;2(3):167-171. Available from: https://sid.ir/paper/286967/en

IEEE: Copy

A. ARZI, and MOHSEN REZAEI, “THE EFFECT OF ORAL ADMINISTRATION OF L-TYROSINE, FOLIC ACID AND PYRIDOXINE ON PERPHENAZINE INDUCED CATATONIA IN RAT,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 2, no. 3, pp. 167–171, 2003, [Online]. Available: https://sid.ir/paper/286967/en

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