HYPNOTIC EFFECT OF ROSA DAMASCENA IN MICE

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RAKHSHANDAH H.; HOSSEINI M.; DOULATI K.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2004 | Volume:3 | Issue:3 Page(s): 181-185

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Information Journal Paper

Title

HYPNOTIC EFFECT OF ROSA DAMASCENA IN MICE

Author(s)

RAKHSHANDAH H. | HOSSEINI M. | DOULATI K. | Issue Writer Certificate

Keywords

MICE

ROSA DAMASCENA

HYPNOTIC EFFECT

PENTOBARBITAL

Abstract

Rosa damascena (Rosaceae) has been found to act on central nervous system including the brain. Several studies confirm that ROSA DAMASCENA inhibits the reactivity of the hypothalamus and pituitary systems in rat and can suppress the reactivity of central nervous system. In traditional medicine the HYPNOTIC EFFECT of rose is also suggested. In the present study HYPNOTIC EFFECT of ethanolic, aqueousand chloroformic extracts of ROSA DAMASCENA was investigated in MICE. Hypnotic method was based on potentiation of PENTOBARBITAL induced sleeping time by extracts. Three doses of extracts (100, 500 and 1000 mg/kg) were injected intraperitoneally in comparisonwith diazepam (3 mg/kg) as the positivecontroland salineas the negative control. Thirty min after injection of extracts, PENTOBARBITAL (30 mg/kg) was injecteci and any increase in the sleeping time due to the extracts was recorded. Results showed that the ethaholic and aqueous extracts in doses of 500 and 1000 mg/kg significantly increased the PENTOBARBITAL induced sleeping time (P<0.001, compared to the negative control), which was comparableto diazepam. The chloroformic extract showed no HYPNOTIC EFFECT.

Cites

THE LAXATIVE AND PROKINETIC EFFECTS OF ROSA DAMASCENA MILL IN RATS

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APA: Copy

RAKHSHANDAH, H., HOSSEINI, M., & DOULATI, K.. (2004). HYPNOTIC EFFECT OF ROSA DAMASCENA IN MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 3(3), 181-185. SID. https://sid.ir/paper/287505/en

Vancouver: Copy

RAKHSHANDAH H., HOSSEINI M., DOULATI K.. HYPNOTIC EFFECT OF ROSA DAMASCENA IN MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2004;3(3):181-185. Available from: https://sid.ir/paper/287505/en

IEEE: Copy

H. RAKHSHANDAH, M. HOSSEINI, and K. DOULATI, “HYPNOTIC EFFECT OF ROSA DAMASCENA IN MICE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 3, no. 3, pp. 181–185, 2004, [Online]. Available: https://sid.ir/paper/287505/en

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