ANTI-ISCHEMIC EFFECT OF NIGELLA SATIVA L. SEED IN MALE RATS

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HOSSEINZADEH H.; JAFARI MOHAMMAD REZA; KHOUEI A.R.; RAHMANI M.

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Journal: Iranian Journal of Pharmaceutical Research Year:2006 | Volume:5 | Issue:1 Page(s): 53-58

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Title

ANTI-ISCHEMIC EFFECT OF NIGELLA SATIVA L. SEED IN MALE RATS

Author(s)

HOSSEINZADEH H. | JAFARI MOHAMMAD REZA | KHOUEI A.R. | RAHMANI M. | Issue Writer Certificate

Keywords

NIGELLA SATIVA SEED

ANTI-ISCHEMIC ACTIVITY

FOUR-VESSEL OCCLUSION

HIPPOCAMPUS

Abstract

The anti-ischemic effect of aqueous and ethanolic extracts of Nigella sativa L. seed was studied using a FOUR-VESSEL OCCLUSION model in rats. The ischemia was evaluated by optical and transmission electron microscopy. After 20 min of forebrain ischemia, agents were administered intraperitoneally after reperfusion. Both extracts comprised an alkaloid. In ischemic rats, the aqueous (1 g/kg) and ethanolic (1.6 g/kg) extracts significantly reduced neural cell injuries in the CA1 and CA3 regions of rat HIPPOCAMPUS. The LD50 values (mice, i.p.) of the aqueous and ethanolic extracts were 1.69 g/kg and 2.25 g/kg, respectively. These results indicate that the N. sativa seed extracts could have a therapeutic effect against cerebral ischemia.

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APA: Copy

HOSSEINZADEH, H., JAFARI, MOHAMMAD REZA, RAHMANI, M., & KHOUEI, A.R.. (2006). ANTI-ISCHEMIC EFFECT OF NIGELLA SATIVA L. SEED IN MALE RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 5(1), 53-58. SID. https://sid.ir/paper/287567/en

Vancouver: Copy

HOSSEINZADEH H., JAFARI MOHAMMAD REZA, RAHMANI M., KHOUEI A.R.. ANTI-ISCHEMIC EFFECT OF NIGELLA SATIVA L. SEED IN MALE RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2006;5(1):53-58. Available from: https://sid.ir/paper/287567/en

IEEE: Copy

H. HOSSEINZADEH, MOHAMMAD REZA JAFARI, M. RAHMANI, and A.R. KHOUEI, “ANTI-ISCHEMIC EFFECT OF NIGELLA SATIVA L. SEED IN MALE RATS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 5, no. 1, pp. 53–58, 2006, [Online]. Available: https://sid.ir/paper/287567/en

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