NASAL IMMUNIZATION BY (PLGA) NANOSPHERES ENCAPSULATED WITH TETANUS TOXOID AND (CPG-ODN)

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAFAGHODI M.; SAJADI TABASI S.A.A.GH.; JAFARI M.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2007 | Volume:6 | Issue:3 Page(s): 151-158

Download Full-Text

View:

373

Download:

133

Cites:

Information Journal Paper

Title

NASAL IMMUNIZATION BY (PLGA) NANOSPHERES ENCAPSULATED WITH TETANUS TOXOID AND (CPG-ODN)

Author(s)

TAFAGHODI M. | SAJADI TABASI S.A.A.GH. | JAFARI M.R. | Issue Writer Certificate

Keywords

NASAL IMMUNIZATION

PLGA

CPG-ODN

NANOSPHERE

TETANUS TOXOID

Abstract

In induction of systemic and mucosal immunity, particulate antigens are more effective than soluble antigens possibly because they are more efficiently endocytosed by mucosal-associated lymphoid tissue (MALT) M cells. In this study, we determined the systemic and mucosal immune responses in rabbits following intraNASAL IMMUNIZATION of TETANUS TOXOID TT and CPG-ODN encapsulated within PLGA NANOSPHEREs. The mean diameter of (TT) and TT+CpG NANOSPHEREs were 753 ±193 and 684±324 nm, respectively. Encapsulation efficiency of TT and CPG-ODN was determined as 52±7.8% and 30.2±7.4% respectively. The highest nasal lavage (sIgA) titers were observed in groups immunized with NANOSPHERE formulations, while the IgG and antitoxin titers were suppressed by these formulations. CPG-ODN as an adjuvant could increase the serum IgG and antitoxin titers when co-administered with TT solution or co-encapsulated with TT in PLGA NANOSPHEREs, but failed to potentiate the 19 Atiters in nasal lavages. No hemolysis was occurred on incubation of PLGA NANOSPHEREs and human (RBCs). Also after nasal administration of plain NANOSPHEREs to human volunteers, no local irritation was seen. Intranasal administration of NANOSPHEREs encapsulated with vaccines showed to be an effective way for inducing mucosal sIgA immune responses, and CPG-ODN could increase the systemic immune responses.

Cites

No record.

References

No record.

Cite

APA: Copy

TAFAGHODI, M., SAJADI TABASI, S.A.A.GH., & JAFARI, M.R.. (2007). NASAL IMMUNIZATION BY (PLGA) NANOSPHERES ENCAPSULATED WITH TETANUS TOXOID AND (CPG-ODN). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 6(3), 151-158. SID. https://sid.ir/paper/287639/en

Vancouver: Copy

TAFAGHODI M., SAJADI TABASI S.A.A.GH., JAFARI M.R.. NASAL IMMUNIZATION BY (PLGA) NANOSPHERES ENCAPSULATED WITH TETANUS TOXOID AND (CPG-ODN). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2007;6(3):151-158. Available from: https://sid.ir/paper/287639/en

IEEE: Copy

M. TAFAGHODI, S.A.A.GH. SAJADI TABASI, and M.R. JAFARI, “NASAL IMMUNIZATION BY (PLGA) NANOSPHERES ENCAPSULATED WITH TETANUS TOXOID AND (CPG-ODN),” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 6, no. 3, pp. 151–158, 2007, [Online]. Available: https://sid.ir/paper/287639/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops