THE EFFECT OF AQUEOUS CROCUS SATIVUS L. EXTRACT ON INTRACEREBROVENTRICULAR STREPTOZOTOCIN-INDUCED COGNITIVE DEFICITS IN RAT: A BEHAVIORAL ANALYSIS

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KHALILI MOHSEN; ROGHANI MEHRDAD; EKHLASI M.

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Journal: Iranian Journal of Pharmaceutical Research Year:2009 | Volume:8 | Issue:3 Page(s): 185-191

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Information Journal Paper

Title

THE EFFECT OF AQUEOUS CROCUS SATIVUS L. EXTRACT ON INTRACEREBROVENTRICULAR STREPTOZOTOCIN-INDUCED COGNITIVE DEFICITS IN RAT: A BEHAVIORAL ANALYSIS

Author(s)

KHALILI MOHSEN | ROGHANI MEHRDAD | EKHLASI M. | Issue Writer Certificate

Keywords

CROCUS SATIVUS L

STREPTOZOTOCIN

LEARNING

MEMORY

SPATIAL COGNITION

RAT

Abstract

Intracerebroventricular (ICV) injection of STREPTOZOTOCIN (STZ) causes cognitive impairment in RATs. The beneficial effect of CROCUS SATIVUS L. extract (CSE) was evaluated on ICV STZ-induced LEARNING, MEMORY, and cognitive impairment in male RATs. For this purpose, RATs were injected with ICV STZ bilaterally, on days 1 and 3 (3 mg/kg). The STZ-injected RATs received CSE (60 mg/kg; i.p.) every other day, starting one day before surgery, for three weeks. The LEARNING and MEMORY performance was assessed using passive avoidance paradigm, and for SPATIAL COGNITION evaluation, Y-maze task was used. It was found that CSE-treated STZ-injected RATs show higher correct choices and lower errors in Y maze than vehicle-treated STZ-injected RATs. In addition, CSE administration significantly attenuated LEARNING and MEMORY impairment in treated STZ-injected group in passive avoidance test. Therefore, these results demonstrate the effectiveness of CSE in preventing the cognitive deficits caused by ICV STZ in RATs and its potential in the treatment of neurodegenerative diseases such as Alzheimer’s disease (AD).

Cites

A REVIEW ON THE EFFECTS OF SAFFRON EXTRACT AND ITS CONSTITUENTS ON FACTORS RELATED TO NEUROLOGIC, CARDIOVASCULAR AND GASTROINTESTINAL DISEASES

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APA: Copy

KHALILI, MOHSEN, ROGHANI, MEHRDAD, & EKHLASI, M.. (2009). THE EFFECT OF AQUEOUS CROCUS SATIVUS L. EXTRACT ON INTRACEREBROVENTRICULAR STREPTOZOTOCIN-INDUCED COGNITIVE DEFICITS IN RAT: A BEHAVIORAL ANALYSIS . IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 8(3), 185-191. SID. https://sid.ir/paper/287723/en

Vancouver: Copy

KHALILI MOHSEN, ROGHANI MEHRDAD, EKHLASI M.. THE EFFECT OF AQUEOUS CROCUS SATIVUS L. EXTRACT ON INTRACEREBROVENTRICULAR STREPTOZOTOCIN-INDUCED COGNITIVE DEFICITS IN RAT: A BEHAVIORAL ANALYSIS . IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2009;8(3):185-191. Available from: https://sid.ir/paper/287723/en

IEEE: Copy

MOHSEN KHALILI, MEHRDAD ROGHANI, and M. EKHLASI, “THE EFFECT OF AQUEOUS CROCUS SATIVUS L. EXTRACT ON INTRACEREBROVENTRICULAR STREPTOZOTOCIN-INDUCED COGNITIVE DEFICITS IN RAT: A BEHAVIORAL ANALYSIS ,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 8, no. 3, pp. 185–191, 2009, [Online]. Available: https://sid.ir/paper/287723/en

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