ANTIHYPERTENSIVE EFFECTS OF SOME NEW NITROXYALKYL 1,4-DIHYDROPYRIDINE DERIVATIVES IN RAT MODEL OF 
TWO-KIDNEY, ONE-CLIP HYPERTENSION

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NEKOUEIAN A.A.; KHALILI A.; JAVIDNIA KATAYOUN; MAHDIPOUR A.R.; MIRI RAMIN

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Journal: Iranian Journal of Pharmaceutical Research Year:2009 | Volume:8 | Issue:3 Page(s): 193-199

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Title

ANTIHYPERTENSIVE EFFECTS OF SOME NEW NITROXYALKYL 1,4-DIHYDROPYRIDINE DERIVATIVES IN RAT MODEL OF TWO-KIDNEY, ONE-CLIP HYPERTENSION

Author(s)

Keywords

TWO-KIDNEY

ONE-CLIP HYPERTENSION

4-DIHYDROPYRIDINES

MAP

Abstract

Dihydropyridine calcium channel blockers consist one of the widely-used groups of drugs for the management of hypertension. In this study, antihypertensive effects of 5 newly synthesized derivatives of DHP was examined the in rat model of TWO-KIDNEY, one-clip renal hypertension. The results showed that those compounds containing two nitroxy groups had less decreasing effect on MAP (Men Arterial Pressure) compared to those having one nitroxy group in 5 position. On the other hand, conformational analysis indicated that in two compounds with two chains (A and E), a great steric hindrance existed; therefore, steric hindrance is the most important factor for interaction of compounds with their receptors.

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APA: Copy

NEKOUEIAN, A.A., KHALILI, A., JAVIDNIA, KATAYOUN, MAHDIPOUR, A.R., & MIRI, RAMIN. (2009). ANTIHYPERTENSIVE EFFECTS OF SOME NEW NITROXYALKYL 1,4-DIHYDROPYRIDINE DERIVATIVES IN RAT MODEL OF TWO-KIDNEY, ONE-CLIP HYPERTENSION . IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 8(3), 193-199. SID. https://sid.ir/paper/287725/en

Vancouver: Copy

NEKOUEIAN A.A., KHALILI A., JAVIDNIA KATAYOUN, MAHDIPOUR A.R., MIRI RAMIN. ANTIHYPERTENSIVE EFFECTS OF SOME NEW NITROXYALKYL 1,4-DIHYDROPYRIDINE DERIVATIVES IN RAT MODEL OF TWO-KIDNEY, ONE-CLIP HYPERTENSION . IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2009;8(3):193-199. Available from: https://sid.ir/paper/287725/en

IEEE: Copy

A.A. NEKOUEIAN, A. KHALILI, KATAYOUN JAVIDNIA, A.R. MAHDIPOUR, and RAMIN MIRI, “ANTIHYPERTENSIVE EFFECTS OF SOME NEW NITROXYALKYL 1,4-DIHYDROPYRIDINE DERIVATIVES IN RAT MODEL OF TWO-KIDNEY, ONE-CLIP HYPERTENSION ,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 8, no. 3, pp. 193–199, 2009, [Online]. Available: https://sid.ir/paper/287725/en

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