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Information Journal Paper

Title

THE ROLE OF ESTROGEN RECEPTORS ON SPATIAL LEARNING AND MEMORY IN CA1 REGION OF ADULT MALE RAT HIPPOCAMPUS

Pages

  183-191

Abstract

 The hippocampal system plays an important role in memory function. Neurohormones like androgens and estrogens that syntheses in HIPPOCAMPUS have an important role in learning and memory. Many biological effects of estrogens in the brain via estrogenic receptors (ERs) are investigated. The current research has conducted to assess the effect of estrogenic receptors on spatial discrimination in rats by using Morris water maze (MWM) task. Adult male rats were bilaterally cannulated into CA1 region of HIPPOCAMPUS and divided in to 9 groups. Different groups received dimethyl sulfoxide (DMSO) 0.5 ml as control groups and different doses of TAMOXIFEN (TAX) as antagonist of ER (0.0625, 0.125 and 0.25mg/0.5ml), propyl pyrazol thiol (PPT) as agonist of ERa (5,10 and 20mg/0.5ml), TAX 0.25mg/0.5ml + PPT 20mg/0.5ml all days 30-35 min before training. Our results have shown TAX (0.25mg/0.5ml), PPT (20mg/0.5ml), TAX (0.25mg/0.5ml) + PPT (20mg/0.5ml) groups significantly increase the escape latency and traveled distance to find invisible platform. Our results indicate that TAX and PPT and also TAX (0.25mg/0.5ml) + PPT (20mg/0.5ml) impaired acquisition of SPATIAL LEARNING AND MEMORY. As a consequence, it seems that estrogen modulates memory function via a novel estrogenic mechanism.

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    APA: Copy

    TALEBI, A., NAGHDI, N., SEPEHRI, H., & REZAYOF, A.. (2010). THE ROLE OF ESTROGEN RECEPTORS ON SPATIAL LEARNING AND MEMORY IN CA1 REGION OF ADULT MALE RAT HIPPOCAMPUS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 9(2), 183-191. SID. https://sid.ir/paper/287750/en

    Vancouver: Copy

    TALEBI A., NAGHDI N., SEPEHRI H., REZAYOF A.. THE ROLE OF ESTROGEN RECEPTORS ON SPATIAL LEARNING AND MEMORY IN CA1 REGION OF ADULT MALE RAT HIPPOCAMPUS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2010;9(2):183-191. Available from: https://sid.ir/paper/287750/en

    IEEE: Copy

    A. TALEBI, N. NAGHDI, H. SEPEHRI, and A. REZAYOF, “THE ROLE OF ESTROGEN RECEPTORS ON SPATIAL LEARNING AND MEMORY IN CA1 REGION OF ADULT MALE RAT HIPPOCAMPUS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 9, no. 2, pp. 183–191, 2010, [Online]. Available: https://sid.ir/paper/287750/en

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