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Information Journal Paper

Title

THE SELECTIVE CYCLOOXYGENASE-2 INHIBITOR, THE COMPOUND 11B IMPROVES HALOPERIDOL INDUCED CATATONIA BY ENHANCING THE STRIATUM DOPAMINERGIC NEUROTRANSMISSION

Pages

  387-393

Abstract

 A substantial amount of evidence has proposed an important role for Cyclooxygenase-2 (COX-2) enzyme in brain diseases and affiliate disorders. The purpose of this research was studying the effects of COX-2 selective inhibition on haloperidol-induced catatonia in an animal model of drug overdose and Parkinson’s disease (PD). In this study, the effect of acute and Sub-chronic oral administration of a new selective COX-2 inhibitor, i.e. the COMPOUND 11B or 1- (Phenyl) -5- (4-methylsulfonylphenyl) -2-ethylthioimidazole, in a dosage of 2, 4 and 8 mg/kg on haloperidol-induced catatonia was evaluated and compared to the standard drug scopolamine (1 mg/kg) by microanalysis of Striatum DOPAMINERGIC NEUROTRANSMISSION. The results showed a very high potency for 11b in improving the CATALEPSY by enhancing the dopaminergic neurotranmission (p<0.05). In addition, statistical analysis showed the dose- and time-dependent behavior of the observed protective effect of 11b against the haloperidol-induced catatonia and enhancement of the DOPAMINERGIC NEUROTRANSMISSION. These findings are additional pharmacological data that suggest the effectiveness of COX-2 inhibition in treatment of schizophreny-associated rigidity.

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    APA: Copy

    FATHI MOGHADDAM, HADI, SHAFIEE ARDESTANI, MEHDI, SAFFARI, MOSTAFA, JABBARI ARABZADEH, ALI, & ELMI, MITRA. (2010). THE SELECTIVE CYCLOOXYGENASE-2 INHIBITOR, THE COMPOUND 11B IMPROVES HALOPERIDOL INDUCED CATATONIA BY ENHANCING THE STRIATUM DOPAMINERGIC NEUROTRANSMISSION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 9(4), 387-393. SID. https://sid.ir/paper/287817/en

    Vancouver: Copy

    FATHI MOGHADDAM HADI, SHAFIEE ARDESTANI MEHDI, SAFFARI MOSTAFA, JABBARI ARABZADEH ALI, ELMI MITRA. THE SELECTIVE CYCLOOXYGENASE-2 INHIBITOR, THE COMPOUND 11B IMPROVES HALOPERIDOL INDUCED CATATONIA BY ENHANCING THE STRIATUM DOPAMINERGIC NEUROTRANSMISSION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2010;9(4):387-393. Available from: https://sid.ir/paper/287817/en

    IEEE: Copy

    HADI FATHI MOGHADDAM, MEHDI SHAFIEE ARDESTANI, MOSTAFA SAFFARI, ALI JABBARI ARABZADEH, and MITRA ELMI, “THE SELECTIVE CYCLOOXYGENASE-2 INHIBITOR, THE COMPOUND 11B IMPROVES HALOPERIDOL INDUCED CATATONIA BY ENHANCING THE STRIATUM DOPAMINERGIC NEUROTRANSMISSION,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 9, no. 4, pp. 387–393, 2010, [Online]. Available: https://sid.ir/paper/287817/en

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