SYNTHESIS AND DETERMINATION OF CHRONIC AND ACUTE THERMAL AND CHEMICAL PAIN ACTIVITIES OF A NEW DERIVATIVE OF PHENCYCLIDINE IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AHMADI ABBAS; KHALILI MOHSEN; HAJIKHANI RAMIN; BARGHI LEILA; MIHANDOUST FARNAZ

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2010 | Volume:9 | Issue:4 Page(s): 379-385

Download Full-Text

View:

333

Download:

138

Cites:

Information Journal Paper

Title

SYNTHESIS AND DETERMINATION OF CHRONIC AND ACUTE THERMAL AND CHEMICAL PAIN ACTIVITIES OF A NEW DERIVATIVE OF PHENCYCLIDINE IN RATS

Author(s)

Keywords

PHENCYCLIDINE

KETAMINE

1-TETRALONE DERIVATIVES

TAIL IMMERSION TEST

FORMALIN TEST

ACUTE AND CHRONIC PAIN

Abstract

PHENCYCLIDINE (1- (1-phenylcyclohexyl) piperidine, PCP, I) and KETAMINE (2-O -chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1- [1- (3-methoxyphenyl) (tetralyl1)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain of this compound was determined using TAIL IMMERSION TEST on rats and the results were compared with KETAMINE and PCP.The results indicated a marked anti-nociception 2-25 min after KETAMINE injection, but the analgesic effect remained for 40 min following PCP-OCH3-tetralyl application in TAIL IMMERSION TEST. However, the data obtained from FORMALIN TEST showed that the chronic anti-nociception effect of KETAMINE was higher than PCP and PCP-OCH3-tetralyl exhibited almost similar analgesic effect.

Cites

No record.

References

No record.

Cite

APA: Copy

AHMADI, ABBAS, KHALILI, MOHSEN, HAJIKHANI, RAMIN, BARGHI, LEILA, & MIHANDOUST, FARNAZ. (2010). SYNTHESIS AND DETERMINATION OF CHRONIC AND ACUTE THERMAL AND CHEMICAL PAIN ACTIVITIES OF A NEW DERIVATIVE OF PHENCYCLIDINE IN RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 9(4), 379-385. SID. https://sid.ir/paper/287827/en

Vancouver: Copy

AHMADI ABBAS, KHALILI MOHSEN, HAJIKHANI RAMIN, BARGHI LEILA, MIHANDOUST FARNAZ. SYNTHESIS AND DETERMINATION OF CHRONIC AND ACUTE THERMAL AND CHEMICAL PAIN ACTIVITIES OF A NEW DERIVATIVE OF PHENCYCLIDINE IN RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2010;9(4):379-385. Available from: https://sid.ir/paper/287827/en

IEEE: Copy

ABBAS AHMADI, MOHSEN KHALILI, RAMIN HAJIKHANI, LEILA BARGHI, and FARNAZ MIHANDOUST, “SYNTHESIS AND DETERMINATION OF CHRONIC AND ACUTE THERMAL AND CHEMICAL PAIN ACTIVITIES OF A NEW DERIVATIVE OF PHENCYCLIDINE IN RATS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 9, no. 4, pp. 379–385, 2010, [Online]. Available: https://sid.ir/paper/287827/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops