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Information Journal Paper

Title

FORMULATION AND EVALUATION OF A NOVEL MATRIX-TYPE ORALLY DISINTEGRATING IBUPROFEN TABLET

Pages

  469-479

Abstract

 Orally disintegrating tablets (ODTs) are capable of turning quickly into a liquid dosage form in contact with the saliva, thus possessing the advantages of both the solid dosage forms particularly stability and liquid dosage forms specially ease of swallowing and pre-gastric absorption of drug. The aim of this study was to prepare a novel matrix-type buccal fast disintegrating IBUPROFEN tablet formulation using special polymers, water soluble excipients, super-disintegrants and quickly soluble granules. For this purpose different tablet formulations of IBUPROFEN were prepared. The amount of IBUPROFEN in each formulation was 100 mg. Eight groups of formulation were prepared (A-H series), accounting for a total number of 45 formulations. Formulations prepared were examined in terms of different physicochemical tests including powder/granule flowability, appearance, thickness, uniformity of weight, hardness, friability and disintegration time. Results of formulation F22a (in series F), was found to be acceptable, making it the chosen formulation for further studies. Then, by adding various flavorants and sweeteners to this formulation, complementary series of formulations, named G and H, were prepared. Following the comparison of their taste with each other through asking 10 volunteers, the most suitable formulation regarding the taste, being formulation F22s, was chosen as the ultimate formulation. This formulation had PVP, IBUPROFEN and CROSCARMELLOSE as the intra-granular components and XYLITOL and saccharin as the extra-granular ingredients. Formulation F22s was found to be acceptable in terms of physicochemical tests conducted, showing quick disintegration within the buccal cavity, appropriate hardness and rather low friability. Hence formulation F22s was selected as the final formulation.

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    • Cite

    APA: Copy

    TAYEBI, HODA, & MORTAZAVI, SEYED ALIREZA. (2011). FORMULATION AND EVALUATION OF A NOVEL MATRIX-TYPE ORALLY DISINTEGRATING IBUPROFEN TABLET. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 10(3), 469-479. SID. https://sid.ir/paper/287834/en

    Vancouver: Copy

    TAYEBI HODA, MORTAZAVI SEYED ALIREZA. FORMULATION AND EVALUATION OF A NOVEL MATRIX-TYPE ORALLY DISINTEGRATING IBUPROFEN TABLET. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2011;10(3):469-479. Available from: https://sid.ir/paper/287834/en

    IEEE: Copy

    HODA TAYEBI, and SEYED ALIREZA MORTAZAVI, “FORMULATION AND EVALUATION OF A NOVEL MATRIX-TYPE ORALLY DISINTEGRATING IBUPROFEN TABLET,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 10, no. 3, pp. 469–479, 2011, [Online]. Available: https://sid.ir/paper/287834/en

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