ANTITUMOR ACTIVITY OF PROSOPIS GLANDULOSA TORR. ON EHRLICH ASCITES CARCINOMA (EAC) TUMOR BEARING MICE

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KUMAR RAJU SENTHIL; RAJKAPOOR BALASUBRAMANIAN; PERUMAL PERUMAL; DHANASEKARAN THANGAVEL; JOSE MANONMANI ALVIN; JOTHIMANIVANNAN CHENNAKESAVALU

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Journal: Iranian Journal of Pharmaceutical Research Year:2011 | Volume:10 | Issue:3 Page(s): 505-510

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Title

ANTITUMOR ACTIVITY OF PROSOPIS GLANDULOSA TORR. ON EHRLICH ASCITES CARCINOMA (EAC) TUMOR BEARING MICE

Author(s)

Keywords

PROSOPIS GLANDULOSA

EHRLICH ASCITES CARCINOMA

LIFE SPAN

HEMATOLOGICAL PARAMETERS

SOLID TUMOR

Abstract

The antitumor activity of ethanol extract of PROSOPIS GLANDULOSA Torr. (EPG) was evaluated against EHRLICH ASCITES CARCINOMA (EAC) tumor model in Swiss albino mice on dose dependent manner. The activity was assessed using survival time, average increase in body weight, HEMATOLOGICAL PARAMETERS and SOLID TUMOR volume. Oral administration of EPG at the dose of 100, 200 and 400 mg/Kg, significantly (p<0.001) increased the survival time and decreased the average body weight of the tumor bearing mice. After 14 days of inoculation, EPG was able to reverse the changes in the HEMATOLOGICAL PARAMETERS, protein and PCV consequent to tumor inoculation. Oral administration of EPG was effective in reducing SOLID TUMOR mass development induced by EAC cells. The results indicate that EPG possess significant antitumor activity on dose dependent manner.

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APA: Copy

KUMAR, RAJU SENTHIL, RAJKAPOOR, BALASUBRAMANIAN, PERUMAL, PERUMAL, DHANASEKARAN, THANGAVEL, JOSE, MANONMANI ALVIN, & JOTHIMANIVANNAN, CHENNAKESAVALU. (2011). ANTITUMOR ACTIVITY OF PROSOPIS GLANDULOSA TORR. ON EHRLICH ASCITES CARCINOMA (EAC) TUMOR BEARING MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 10(3), 505-510. SID. https://sid.ir/paper/287836/en

Vancouver: Copy

KUMAR RAJU SENTHIL, RAJKAPOOR BALASUBRAMANIAN, PERUMAL PERUMAL, DHANASEKARAN THANGAVEL, JOSE MANONMANI ALVIN, JOTHIMANIVANNAN CHENNAKESAVALU. ANTITUMOR ACTIVITY OF PROSOPIS GLANDULOSA TORR. ON EHRLICH ASCITES CARCINOMA (EAC) TUMOR BEARING MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2011;10(3):505-510. Available from: https://sid.ir/paper/287836/en

IEEE: Copy

RAJU SENTHIL KUMAR, BALASUBRAMANIAN RAJKAPOOR, PERUMAL PERUMAL, THANGAVEL DHANASEKARAN, MANONMANI ALVIN JOSE, and CHENNAKESAVALU JOTHIMANIVANNAN, “ANTITUMOR ACTIVITY OF PROSOPIS GLANDULOSA TORR. ON EHRLICH ASCITES CARCINOMA (EAC) TUMOR BEARING MICE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 10, no. 3, pp. 505–510, 2011, [Online]. Available: https://sid.ir/paper/287836/en

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