FLOATING MATRIX TABLETS OF DOMPERIDONE FORMULATION AND OPTIMIZATION USING SIMPLEX LATTICE DESIGN

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PRAJAPATI SHAILESH; PATEL LAXMANBHAI; PATEL CHHAGANBHAI

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2011 | Volume:10 | Issue:3 Page(s): 447-455

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Information Journal Paper

Title

FLOATING MATRIX TABLETS OF DOMPERIDONE FORMULATION AND OPTIMIZATION USING SIMPLEX LATTICE DESIGN

Author(s)

PRAJAPATI SHAILESH | PATEL LAXMANBHAI | PATEL CHHAGANBHAI | Issue Writer Certificate

Keywords

DOMPERIDONE

FLOATING MATRIX TABLETS

SIMPLEX LATTICE DESIGN

RELEASE KINETICS

POLYETHYLENE OXIDE

HYDROXYPROPYL METHYLCELLULOSE

FLOATING LAG TIME

TOTAL FLOATING TIME

Abstract

The purpose of this research was to prepare a floating matrix tablet containing DOMPERIDONE as a model drug. POLYETHYLENE OXIDE (PEO) and HYDROXYPROPYL METHYLCELLULOSE (HPMC) were evaluated for matrix-forming properties. A SIMPLEX LATTICE DESIGN was applied to systemically optimize the drug release profile. The amounts of PEO WSR 303, HPMC K15M and sodium bicarbonate were selected as independent variables and FLOATING LAG TIME, time required to release 50% of drug (t50) and 80% of drug (t80), diffusion coefficient (n) and release rate (k) as dependent variables. The amount of PEO and HPMC both had significant influence on the dependent variables. It was found that the content of PEO had dominating role as drug release controlling factor, but using suitable concentration of sodium bicarbonate, one can tailor the desired drug release from hydrophilic matrixes. The linear regression analysis and model fitting showed that all these formulations followed Korsmeyer and Peppas model, which had a higher value of correlation coefficient (r). The tablets of promising formulation were found to be stable for 3 months under accelerated (40oC / 75% RH) stability testing.

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APA: Copy

PRAJAPATI, SHAILESH, PATEL, LAXMANBHAI, & PATEL, CHHAGANBHAI. (2011). FLOATING MATRIX TABLETS OF DOMPERIDONE FORMULATION AND OPTIMIZATION USING SIMPLEX LATTICE DESIGN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 10(3), 447-455. SID. https://sid.ir/paper/287839/en

Vancouver: Copy

PRAJAPATI SHAILESH, PATEL LAXMANBHAI, PATEL CHHAGANBHAI. FLOATING MATRIX TABLETS OF DOMPERIDONE FORMULATION AND OPTIMIZATION USING SIMPLEX LATTICE DESIGN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2011;10(3):447-455. Available from: https://sid.ir/paper/287839/en

IEEE: Copy

SHAILESH PRAJAPATI, LAXMANBHAI PATEL, and CHHAGANBHAI PATEL, “FLOATING MATRIX TABLETS OF DOMPERIDONE FORMULATION AND OPTIMIZATION USING SIMPLEX LATTICE DESIGN,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 10, no. 3, pp. 447–455, 2011, [Online]. Available: https://sid.ir/paper/287839/en

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