مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

PROTECTIVE EFFECT OF RUTIN AND NARINGIN ON SPERM QUALITY IN STREPTOZOTOCIN (STZ) INDUCED TYPE 1 DIABETIC RATS

Pages

  585-596

Abstract

 Oxidative stress is one of the important causes of the TYPE 1 DIABETES induced changes in the sperm quality. Bioflavonoids, RUTIN 10 mg/Kg and NARINGIN 10 mg/Kg were evaluated for their protective effects on sperm parameters, OXIDATIVE STRESS, and histopathology of type 1 diabetic rats. Results demonstrated the reduction in sperm count, sperm motility and vitality in diabetic rate. Mass drug administration (MDA) levels were increased and superoxide dismutase (SOD) catalase levels were decreased. Histopathological changes were evident and in accordance with the above results. In the treatment groups, both RUTIN and NARINGIN in combination with insulin treatment in diabetic rate produced protection from diabetes and improved all the sperm parameters,  decreased the MDA levels and increased the SOD and catalase levels. Protection was evident in histological examination. Our data suggests that the possible protection of testicular tissue and reproduction from OXIDATIVE STRESS have been induced by TYPE 1 DIABETES mellitus.

Cites

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    • Cite

    APA: Copy

    BUTCHI, RAJU AKONDI, KUMAR, PHANI, AKULA, ANNAPURNA, & PUJARI, MANASA. (2011). PROTECTIVE EFFECT OF RUTIN AND NARINGIN ON SPERM QUALITY IN STREPTOZOTOCIN (STZ) INDUCED TYPE 1 DIABETIC RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 10(3), 585-596. SID. https://sid.ir/paper/287864/en

    Vancouver: Copy

    BUTCHI RAJU AKONDI, KUMAR PHANI, AKULA ANNAPURNA, PUJARI MANASA. PROTECTIVE EFFECT OF RUTIN AND NARINGIN ON SPERM QUALITY IN STREPTOZOTOCIN (STZ) INDUCED TYPE 1 DIABETIC RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2011;10(3):585-596. Available from: https://sid.ir/paper/287864/en

    IEEE: Copy

    RAJU AKONDI BUTCHI, PHANI KUMAR, ANNAPURNA AKULA, and MANASA PUJARI, “PROTECTIVE EFFECT OF RUTIN AND NARINGIN ON SPERM QUALITY IN STREPTOZOTOCIN (STZ) INDUCED TYPE 1 DIABETIC RATS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 10, no. 3, pp. 585–596, 2011, [Online]. Available: https://sid.ir/paper/287864/en

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