SYNTHESIS AND ANTIMYCOBACTERIAL ACTIVITY OF 2- (PHENYLTHIO) BENZOYLARYLHYDRAZONE DERIVATIVES

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ALMASIRAD ALI; SAMIEE SADR SOMAYEH; SHAFIEE ABBAS

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2011 | Volume:10 | Issue:4 Page(s): 727-731

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Information Journal Paper

Title

SYNTHESIS AND ANTIMYCOBACTERIAL ACTIVITY OF 2- (PHENYLTHIO) BENZOYLARYLHYDRAZONE DERIVATIVES

Author(s)

ALMASIRAD ALI | SAMIEE SADR SOMAYEH | SHAFIEE ABBAS | Issue Writer Certificate

Keywords

HYDRAZONES

ANTIMYCOBACTERIAL ACTIVITY

MYCOBACTERIUM TUBERCULOSIS

5-NITROFURAN

5-NITROTHIOPHEN

Abstract

A series of new 2- (phenylthio) benzoylaryl HYDRAZONES were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. The chemical structures of the compounds were elucidated by FT-IR, 1H-NMR and Mass spectra. All newly synthesized compounds were evaluated for their antimycobacterial activities against MYCOBACTERIUM TUBERCULOSIS H37Rv using the microplate alamar blue assay (MABA). Compounds 4f (5-Nitro-2-furyl analogue) and 4g (5-Nitro-2-thienyl analogue) showed ANTIMYCOBACTERIAL ACTIVITY with IC90, 7.57 and 2.96 mg/mL, respectively.

Cites

SYNTHESIS OF NEW 1, 3-THIAZOLINE-2-THIONES AS POTENTIAL ANTIMYCOBACTERIAL AGENTS

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APA: Copy

ALMASIRAD, ALI, SAMIEE SADR, SOMAYEH, & SHAFIEE, ABBAS. (2011). SYNTHESIS AND ANTIMYCOBACTERIAL ACTIVITY OF 2- (PHENYLTHIO) BENZOYLARYLHYDRAZONE DERIVATIVES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 10(4), 727-731. SID. https://sid.ir/paper/287881/en

Vancouver: Copy

ALMASIRAD ALI, SAMIEE SADR SOMAYEH, SHAFIEE ABBAS. SYNTHESIS AND ANTIMYCOBACTERIAL ACTIVITY OF 2- (PHENYLTHIO) BENZOYLARYLHYDRAZONE DERIVATIVES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2011;10(4):727-731. Available from: https://sid.ir/paper/287881/en

IEEE: Copy

ALI ALMASIRAD, SOMAYEH SAMIEE SADR, and ABBAS SHAFIEE, “SYNTHESIS AND ANTIMYCOBACTERIAL ACTIVITY OF 2- (PHENYLTHIO) BENZOYLARYLHYDRAZONE DERIVATIVES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 10, no. 4, pp. 727–731, 2011, [Online]. Available: https://sid.ir/paper/287881/en

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