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Title

EFFECTS OF PARSLEY (PETROSELINUM CRISPUM) AND ITS FLAVONOL CONSTITUENTS, KAEMPFEROL AND QUERCETIN, ON SERUM URIC ACID LEVELS, BIOMARKERS OF OXIDATIVE STRESS AND LIVER XANTHINE OXIDOREDUCTASE AACTIVITY INOXONATE-INDUCED HYPERURICEMIC RATS

Pages

  811-819

Abstract

 Increased serum uric acid is known to be a major risk related to the development of several OXIDATIVE STRESS diseases. The aim of this study was to investigate the effect of parsley, QUERCETIN and KAEMPFEROL on serum uric acid levels, liver XANTHINE OXIDOREDUCTASE activity and two non-invasive biomarkers of OXIDATIVE STRESS (total antioxidant capacity and malondialdehyde concentration) in normal and oxonate-induced hyperuricemic rats. A total of 60 male Wistar rats were randomly divided into ten equal groups; including 5 normal groups (vehicle, parsley, QUERCETIN, KAEMPFEROL and allopurinol) and 5 hyperuricemic groups (vehicle, parsley, QUERCETIN, KAEMPFEROL and allopurinol). Parsley (5 g/Kg), QUERCETIN (5 mg/Kg), KAEMPFEROL (5 mg/Kg) and allopurinol (5 mg/Kg) were administrated to the corresponding groups by oral gavage once a day for 2 weeks. The results showed that parsley and its flavonol did not cause any significant reduction in the serum uric acid levels in normal rats, but significantly reduced the serum uric acid levels of hyperuricemic rats in a time-dependent manner. All treatments significantly inhibited liver XANTHINE OXIDOREDUCTASE activity. Parsley, KAEMPFEROL and QUERCETIN treatment led also to a significant increase in total antioxidant capacity and decrease in malondialdehyde concentration in hyperuricemic rats. Although the hypouricemic effect of allopurinol was much higher than that of parsley and its flavonol constituents, it could not significantly change OXIDATIVE STRESS biomarkers. These features of parsley and its flavonols make them as a possible alternative for allopurinol, or at least in combination therapy to minimize the side effects of allopurinol to treat HYPERURICEMIA and OXIDATIVE STRESS diseases.

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    APA: Copy

    HAIDARI, FATEMEH, KESHAVARZ, SEID ALI, MOHAMMAD SHAHI, MAJID, MAHBOOB, SOLTAN ALI, & RASHIDI, MOHAMMAD REZA. (2011). EFFECTS OF PARSLEY (PETROSELINUM CRISPUM) AND ITS FLAVONOL CONSTITUENTS, KAEMPFEROL AND QUERCETIN, ON SERUM URIC ACID LEVELS, BIOMARKERS OF OXIDATIVE STRESS AND LIVER XANTHINE OXIDOREDUCTASE AACTIVITY INOXONATE-INDUCED HYPERURICEMIC RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 10(4), 811-819. SID. https://sid.ir/paper/287896/en

    Vancouver: Copy

    HAIDARI FATEMEH, KESHAVARZ SEID ALI, MOHAMMAD SHAHI MAJID, MAHBOOB SOLTAN ALI, RASHIDI MOHAMMAD REZA. EFFECTS OF PARSLEY (PETROSELINUM CRISPUM) AND ITS FLAVONOL CONSTITUENTS, KAEMPFEROL AND QUERCETIN, ON SERUM URIC ACID LEVELS, BIOMARKERS OF OXIDATIVE STRESS AND LIVER XANTHINE OXIDOREDUCTASE AACTIVITY INOXONATE-INDUCED HYPERURICEMIC RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2011;10(4):811-819. Available from: https://sid.ir/paper/287896/en

    IEEE: Copy

    FATEMEH HAIDARI, SEID ALI KESHAVARZ, MAJID MOHAMMAD SHAHI, SOLTAN ALI MAHBOOB, and MOHAMMAD REZA RASHIDI, “EFFECTS OF PARSLEY (PETROSELINUM CRISPUM) AND ITS FLAVONOL CONSTITUENTS, KAEMPFEROL AND QUERCETIN, ON SERUM URIC ACID LEVELS, BIOMARKERS OF OXIDATIVE STRESS AND LIVER XANTHINE OXIDOREDUCTASE AACTIVITY INOXONATE-INDUCED HYPERURICEMIC RATS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 10, no. 4, pp. 811–819, 2011, [Online]. Available: https://sid.ir/paper/287896/en

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