A DRUG UTILIZATION EVALUATION STUDY OF AMPHOTERICIN B IN NEUTROPENIC PATIENTS IN A TEACHING HOSPITAL IN IRAN

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TAVAKOLI ARDAKANI MARIA; ESHRAGHI AZADEH; HAJHOSSEIN TALASAZ AZITA; SALAMZADEH JAMSHID

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:1 Page(s): 151-156

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Title

A DRUG UTILIZATION EVALUATION STUDY OF AMPHOTERICIN B IN NEUTROPENIC PATIENTS IN A TEACHING HOSPITAL IN IRAN

Author(s)

TAVAKOLI ARDAKANI MARIA | ESHRAGHI AZADEH | HAJHOSSEIN TALASAZ AZITA | SALAMZADEH JAMSHID | Issue Writer Certificate

Keywords

AMPHOTERICIN B

DRUG UTILIZATION EVALUATION (DUE)

FEBRILE NEUTROPENIA

Abstract

Drug Utilization Evaluation (DUE) studies facilitate assessing the appropriateness and rational use of medications. The goal of the present study was to evaluate AMPHOTERICIN B usage in neutropenic patients. A prospective DUE study was performed in Hematology-Oncology and Stem Cell Transplantation wards at Taleghani hospital for one-year. National comprehensive cancer network, clinical practice guidelines in oncology, American Hospital Formulary Service and other relevant medical practice and up-to dated articles were used to evaluate whether AMPHOTERICIN B is properly used according to the guidelines. All data collected by a pharmacistin daily review using information of physician and nursing records as well as laboratory findings. During the one-year study, 35 patients receiving AMPHOTERICIN B were evaluated.29 patients (82.9%) received AMPHOTERICIN B due to neutropenia and fever and 6 patients had confirmed fungal infections. All of the injectable solutions of AMPHOTERICIN B were appropriately prepared for intravenous infusion. In addition, for all patients, ordering (indication) of the study drug was in accordance with the guidelines. Twenty-five (71.4%) patients received an appropriate dose according to the guidelines. Duration of treatment was properly selected in 21 (60%) patients. Twenty-two (62.8%) patients developed hypokalemia as the most frequent adverse drug event. Although, preparation and indication of AMPHOTERICIN B was in compliance with the current guidelines, dosage and duration of treatment were considered to be incoherent with the designed protocol used in this study. We conclude more attention should be paid to dosage and duration of treatment with AMPHOTERICIN B in order to optimize its administration.

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APA: Copy

TAVAKOLI ARDAKANI, MARIA, ESHRAGHI, AZADEH, HAJHOSSEIN TALASAZ, AZITA, & SALAMZADEH, JAMSHID. (2012). A DRUG UTILIZATION EVALUATION STUDY OF AMPHOTERICIN B IN NEUTROPENIC PATIENTS IN A TEACHING HOSPITAL IN IRAN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(1), 151-156. SID. https://sid.ir/paper/287901/en

Vancouver: Copy

TAVAKOLI ARDAKANI MARIA, ESHRAGHI AZADEH, HAJHOSSEIN TALASAZ AZITA, SALAMZADEH JAMSHID. A DRUG UTILIZATION EVALUATION STUDY OF AMPHOTERICIN B IN NEUTROPENIC PATIENTS IN A TEACHING HOSPITAL IN IRAN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(1):151-156. Available from: https://sid.ir/paper/287901/en

IEEE: Copy

MARIA TAVAKOLI ARDAKANI, AZADEH ESHRAGHI, AZITA HAJHOSSEIN TALASAZ, and JAMSHID SALAMZADEH, “A DRUG UTILIZATION EVALUATION STUDY OF AMPHOTERICIN B IN NEUTROPENIC PATIENTS IN A TEACHING HOSPITAL IN IRAN,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 1, pp. 151–156, 2012, [Online]. Available: https://sid.ir/paper/287901/en

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