PHYTOCHEMICAL ANALYSIS AND METAL-CHELATION ACTIVITY OF ACHILLEA TENUIFOLIA LAM

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MORADKHANI SHIRIN; AYATOLLAHI ABDUL MAJID; GHANADIAN MUSTAFA; MOIN MOHAMMAD REZA; RAZAVIZADEH MASOUD; SHAHLAEI MOHSEN

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Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:1 Page(s): 177-183

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Title

PHYTOCHEMICAL ANALYSIS AND METAL-CHELATION ACTIVITY OF ACHILLEA TENUIFOLIA LAM

Author(s)

Keywords

ACHILLEA TENUIFOLIA

IRON OVERLOAD

5-HYDROXY-FLAVONE

QUERCETIN

CHELATION ASSAY

Abstract

ACHILLEA TENUIFOLIA Lam. (Asteraceae) afforded a dichloromethane fraction from which three known compounds b-sitosterol (compound1), 5-hydroxy, 4’, 6, 7-trimethoxy flavone (salvigenin compound 2), and methyl-gallate (compound 3) were isolated for the first time. The structure of isolated compounds was elucidated by different spectroscopic methods. Applying the molar-ratio method, the complexation of salvigenin with Fe (III), Cu (II) and Zn (II), the most abundant type of metal ions in the body, were then evaluated. It was determined that stoichiometric ratio of salvigenin with these cations were as Fe (Salvigenin)2 (H2O)2 and Cu (Salvigenin)2 (H2O)2 in methanolic solution without pH control, while zinc ions didn’t form significant complexes. The results were confirmed more, by computational molecular modeling of the structure of proposed ligand-complexes by semi-imperical PM3 calculations, which determined negative heat of formation for the complexes Fe (III) and Cu (II) ions as -689.7 and -573.5, respectively and proposed chelating affinity of salvigenin in the following order: Fe (III)>Cu (II)>>Zn (II).

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APA: Copy

MORADKHANI, SHIRIN, AYATOLLAHI, ABDUL MAJID, GHANADIAN, MUSTAFA, MOIN, MOHAMMAD REZA, RAZAVIZADEH, MASOUD, & SHAHLAEI, MOHSEN. (2012). PHYTOCHEMICAL ANALYSIS AND METAL-CHELATION ACTIVITY OF ACHILLEA TENUIFOLIA LAM. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(1), 177-183. SID. https://sid.ir/paper/287907/en

Vancouver: Copy

MORADKHANI SHIRIN, AYATOLLAHI ABDUL MAJID, GHANADIAN MUSTAFA, MOIN MOHAMMAD REZA, RAZAVIZADEH MASOUD, SHAHLAEI MOHSEN. PHYTOCHEMICAL ANALYSIS AND METAL-CHELATION ACTIVITY OF ACHILLEA TENUIFOLIA LAM. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(1):177-183. Available from: https://sid.ir/paper/287907/en

IEEE: Copy

SHIRIN MORADKHANI, ABDUL MAJID AYATOLLAHI, MUSTAFA GHANADIAN, MOHAMMAD REZA MOIN, MASOUD RAZAVIZADEH, and MOHSEN SHAHLAEI, “PHYTOCHEMICAL ANALYSIS AND METAL-CHELATION ACTIVITY OF ACHILLEA TENUIFOLIA LAM,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 1, pp. 177–183, 2012, [Online]. Available: https://sid.ir/paper/287907/en

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