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Cites:

1

Information Journal Paper

Title

EFFECT OF PIMPINELLA TIRUPATIENSIS ON OXIDATIVE ENZYMES IN STZ-INDUCED DIABETIC RAT KIDNEY

Pages

  277-286

Abstract

 The present study was aimed to evaluate the therapeutic potential of PIMPINELLA TIRUPATIENSIS (Pt) by assaying the activities of selective MITOCHONDRIAL ENZYMES in streptozotocin induced diabetic rats. Diabetic rats showed a significant (p<0.01) reduction in the activities of oxidative enzymes Succinate dehydrogenase (SDH), Malate dehydrogenase (MDH), Glutamate dehydrogenase (GDH) and isocitrate dehydrogenase (ICDH). Lactate dehydrogenase (LDH) activity was significantly (p<0.01) increased in diabetic rats. The daily oral treatment of PIMPINELLA TIRUPATIENSIS ethyl alcohol extract (750 mg/kg body weight/day) to diabetic rats for 30 days reversed the above changes in a significant (p<0.01) manner. From our observations, we conclude that administration of Pt altered the activities of oxidative enzymes, thereby suggesting its role in mitochondrial energy production. The obtained results were compared with Glibenclamide, a standard anti diabetic drug. Thus, the modulatory effects of Pt on altering these enzymes activities afford a promise for widespread use for treatment of DIABETES in the future.

Cites

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    APA: Copy

    RAJESWARA REDDY, SADDALA, LAVANY, THOPIREDDY, NARASIMHULU, GANAPATHI, & SATHYAVELU REDDY, KESIREDDY. (2012). EFFECT OF PIMPINELLA TIRUPATIENSIS ON OXIDATIVE ENZYMES IN STZ-INDUCED DIABETIC RAT KIDNEY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(1), 277-286. SID. https://sid.ir/paper/287912/en

    Vancouver: Copy

    RAJESWARA REDDY SADDALA, LAVANY THOPIREDDY, NARASIMHULU GANAPATHI, SATHYAVELU REDDY KESIREDDY. EFFECT OF PIMPINELLA TIRUPATIENSIS ON OXIDATIVE ENZYMES IN STZ-INDUCED DIABETIC RAT KIDNEY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(1):277-286. Available from: https://sid.ir/paper/287912/en

    IEEE: Copy

    SADDALA RAJESWARA REDDY, THOPIREDDY LAVANY, GANAPATHI NARASIMHULU, and KESIREDDY SATHYAVELU REDDY, “EFFECT OF PIMPINELLA TIRUPATIENSIS ON OXIDATIVE ENZYMES IN STZ-INDUCED DIABETIC RAT KIDNEY,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 1, pp. 277–286, 2012, [Online]. Available: https://sid.ir/paper/287912/en

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