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Information Journal Paper

Title

SELECTIVE CYCLOOXYGENASE-2 INHIBITOR COMPOUND 11B IMPROVES HALOPERIDOL-INDUCED CATATONIA BY ENHANCING THE STRIATUM DOPAMINERGIC NEUROTRANSMISSION

Pages

  339-345

Abstract

 The aim of this research was to investigate the Cyclooxygenase-2 (COX-2) selective inhibition effect on haloperidol-induced catatonia. In this study, the effect of orally, acutely and Sub-chronically administrations of COMPOUND 11B [1- (phenyl) -5- (4-methylsulfonylphenyl) -2-ethylthioimidazole] (2, 4 and 8 mg/kg), a newly SELECTIVE COX-2 INHIBITOR, was investigated against the haloperidol-induced catatonia phenomenon comparing to the standard drug scopolamine (1 mg/Kg) followed by microdialysis analysis of Striatum DOPAMINERGIC NEUROTRANSMISSION. The results showed a great potency for COMPOUND 11B in improvement of CATALEPSY followed by enhancing the DOPAMINERGIC NEUROTRANSMISSION p<0.05. In addition, our statistical analysis showed that the protective effect of COMPOUND 11B against haloperidol-induced catatonia was both dose- and time-dependent. These findings are additional pharmacological data that suggest the effectiveness of COMPOUND 11B in treatment of schizophrenic drug overdoses and also PARKINSON’S DISEASE (PD) affiliated rigidity.

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    APA: Copy

    AGHASADEGHI, MOHAMMAD REZA, SIADAT, SEYYED DAVAR, SHAFIEE ARDESTANI, MEHDI, JABBARI ARABZADEH, ALI, ELMI, MITRA, & FATHI MOGHADDAM, HADI. (2012). SELECTIVE CYCLOOXYGENASE-2 INHIBITOR COMPOUND 11B IMPROVES HALOPERIDOL-INDUCED CATATONIA BY ENHANCING THE STRIATUM DOPAMINERGIC NEUROTRANSMISSION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(1), 339-345. SID. https://sid.ir/paper/287913/en

    Vancouver: Copy

    AGHASADEGHI MOHAMMAD REZA, SIADAT SEYYED DAVAR, SHAFIEE ARDESTANI MEHDI, JABBARI ARABZADEH ALI, ELMI MITRA, FATHI MOGHADDAM HADI. SELECTIVE CYCLOOXYGENASE-2 INHIBITOR COMPOUND 11B IMPROVES HALOPERIDOL-INDUCED CATATONIA BY ENHANCING THE STRIATUM DOPAMINERGIC NEUROTRANSMISSION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(1):339-345. Available from: https://sid.ir/paper/287913/en

    IEEE: Copy

    MOHAMMAD REZA AGHASADEGHI, SEYYED DAVAR SIADAT, MEHDI SHAFIEE ARDESTANI, ALI JABBARI ARABZADEH, MITRA ELMI, and HADI FATHI MOGHADDAM, “SELECTIVE CYCLOOXYGENASE-2 INHIBITOR COMPOUND 11B IMPROVES HALOPERIDOL-INDUCED CATATONIA BY ENHANCING THE STRIATUM DOPAMINERGIC NEUROTRANSMISSION,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 1, pp. 339–345, 2012, [Online]. Available: https://sid.ir/paper/287913/en

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