PHYSICAL AND CHEMICAL STABILITY OF MYCOPHENOLATE MOFETIL (MMF) SUSPENSION PREPARED AT THE HOSPITAL

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FAHIMI FANAK; BANIASADI SHADI; MORTAZAVI SEYED ALIREZA; DEHGHAN HANIE; ZARGHI AFSHIN

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:1 Page(s): 171-175

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Title

PHYSICAL AND CHEMICAL STABILITY OF MYCOPHENOLATE MOFETIL (MMF) SUSPENSION PREPARED AT THE HOSPITAL

Author(s)

Keywords

EXTEMPORANEOUS PHARMACY

HPLC

MYCOPHENOLATE MOFETIL

STABILITY

SUSPENSION

Abstract

To evaluate the physical and chemical STABILITY of a SUSPENSION of MYCOPHENOLATE MOFETIL (MMF) prepared in the hospital from commercially available MMF capsules and tablets.EXTEMPORANEOUS PHARMACY was used as a feasible method in this experimental study to prepare SUSPENSION form of MMF. SUSPENSION formulations were prepared from both tablets and capsules forms of MMF. Thereafter the STABILITY parameters such as pH, microbial control, thermal and physical STABILITY and particle sizes were evaluated. The amount of MMF, in the SUSPENSION was measured at various time points by HPLC.The HPLC method showed that concentration of SUSPENSIONs prepared from tablets and capsules were 49 mg/mL and 50 mg/mL at time 0, respectively. The effective amount of SUSPENSIONs prepared from capsules was 101% at time 0, 100% after 7 days, 98% after 14 days, and less than 70% after 28 days.According to the obtained results in this study, capsule-based SUSPENSION was stable for as long as 14 days at 5oC. This formulation appears to be clinically acceptable and provides a convenient dosage form for pediatric patients and for adults during the early postoperative period.

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APA: Copy

FAHIMI, FANAK, BANIASADI, SHADI, MORTAZAVI, SEYED ALIREZA, DEHGHAN, HANIE, & ZARGHI, AFSHIN. (2012). PHYSICAL AND CHEMICAL STABILITY OF MYCOPHENOLATE MOFETIL (MMF) SUSPENSION PREPARED AT THE HOSPITAL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(1), 171-175. SID. https://sid.ir/paper/287928/en

Vancouver: Copy

FAHIMI FANAK, BANIASADI SHADI, MORTAZAVI SEYED ALIREZA, DEHGHAN HANIE, ZARGHI AFSHIN. PHYSICAL AND CHEMICAL STABILITY OF MYCOPHENOLATE MOFETIL (MMF) SUSPENSION PREPARED AT THE HOSPITAL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(1):171-175. Available from: https://sid.ir/paper/287928/en

IEEE: Copy

FANAK FAHIMI, SHADI BANIASADI, SEYED ALIREZA MORTAZAVI, HANIE DEHGHAN, and AFSHIN ZARGHI, “PHYSICAL AND CHEMICAL STABILITY OF MYCOPHENOLATE MOFETIL (MMF) SUSPENSION PREPARED AT THE HOSPITAL,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 1, pp. 171–175, 2012, [Online]. Available: https://sid.ir/paper/287928/en

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