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Information Journal Paper

Title

SYNTHESIS OF A NOVEL SILICONIZED ANALOG OF CLOFIBRATE (SILAFIBRATE) AND COMPARISON OF THEIR ANTI-INFLAMMATORY ACTIVITIES

Pages

  91-95

Abstract

 Fibrates, as hypolipidemic drugs known as agonists of peroxisome proliferator-activated receptors, diminish inflammatory responses. Studies have shown that incorporation of a SILICON atom into a drug structure improves its pharmacological potency, modifies its selectivity toward a given target, or changes its metabolic rate, in addition to increasing the lipophilicity of the compounds. A SILICONized analog of CLOFIBRATE, ethyl-2-methyl-2- (4- (trimethylsilyl) phenoxy) propionate was synthesized, whereby the chlorine atom in the phenoxy ring was replaced by a trimethylsilyl group. The ANTI-INFLAMMATORY effects of the SILICONized analog (silafibrate) were evaluated in an air-pouch model of inflammation and compared with those of CLOFIBRATE. Oral administration of both drugs produced a significant ANTI-INFLAMMATORY action by reducing carrageenan induced pouch leukocyte recruitment, exudates production, and granulated tissue weight. The SILICON isostere of CLOFIBRATE has improved ANTI-INFLAMMATORY properties.

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    • Cite

    APA: Copy

    ZIAEE, MOJTABA, SAMINI, MORTEZA, BOLOURTCHIAN, MOHAMMAD, GHAFFARZADEH, MOHAMMAD, AHMADI, MARYAM, EGBAL, MOHAMMAD ALI, KHORRAMI, ARASH, ANDALIB, SINA, MALEKI DIZAJI, NASRIN, & GARJANI, ALIREZA. (2012). SYNTHESIS OF A NOVEL SILICONIZED ANALOG OF CLOFIBRATE (SILAFIBRATE) AND COMPARISON OF THEIR ANTI-INFLAMMATORY ACTIVITIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(1), 91-95. SID. https://sid.ir/paper/287932/en

    Vancouver: Copy

    ZIAEE MOJTABA, SAMINI MORTEZA, BOLOURTCHIAN MOHAMMAD, GHAFFARZADEH MOHAMMAD, AHMADI MARYAM, EGBAL MOHAMMAD ALI, KHORRAMI ARASH, ANDALIB SINA, MALEKI DIZAJI NASRIN, GARJANI ALIREZA. SYNTHESIS OF A NOVEL SILICONIZED ANALOG OF CLOFIBRATE (SILAFIBRATE) AND COMPARISON OF THEIR ANTI-INFLAMMATORY ACTIVITIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(1):91-95. Available from: https://sid.ir/paper/287932/en

    IEEE: Copy

    MOJTABA ZIAEE, MORTEZA SAMINI, MOHAMMAD BOLOURTCHIAN, MOHAMMAD GHAFFARZADEH, MARYAM AHMADI, MOHAMMAD ALI EGBAL, ARASH KHORRAMI, SINA ANDALIB, NASRIN MALEKI DIZAJI, and ALIREZA GARJANI, “SYNTHESIS OF A NOVEL SILICONIZED ANALOG OF CLOFIBRATE (SILAFIBRATE) AND COMPARISON OF THEIR ANTI-INFLAMMATORY ACTIVITIES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 1, pp. 91–95, 2012, [Online]. Available: https://sid.ir/paper/287932/en

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