SYNTHESIS AND CYTOTOXIC EVALUATION OF NOVEL 3-SUBSTITUTED DERIVATIVES OF 2-INDOLINONE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOKHTARI SHAYA; MOSADDEGH MAHMOUD; HAMZELOO MOGHADAM MARYAM; SOLEYMANI ZOHREH; GHAFARI SAEIDEH; KOBARFARD FARZAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:2 Page(s): 411-421

Download Full-Text

View:

281

Download:

118

Cites:

Information Journal Paper

Title

SYNTHESIS AND CYTOTOXIC EVALUATION OF NOVEL 3-SUBSTITUTED DERIVATIVES OF 2-INDOLINONE

Author(s)

Keywords

3- SUBSTITUTED DERIVATIVES OF 2-INDOLINONES

INDOLE DERIVATIVES

CYTOTOXICITY

COLON AND BREAST CANCER

MTT ASSAY

Abstract

The assessment of the degree or rate of cellular proliferation and cell viability is critical for the assessment of the effects of drugs on both normal and malignant cell populations. In the present study, a few novel 3-substituted derivatives of 2-indolinones were synthesized by condensation of substituted oxindole or isatin derivatives with appropriate aldehydes or primary aromatic amines respectively. The synthesized compounds were screened for their CYTOTOXICITY against HT-29 (human colon adenocarcinoma cell line) and MCF-7 (human breast adenocarcinoma cell line) cells using short term CYTOTOXICITY MTT ASSAY protocol. A few derivatives with IC50<10 mM were identified among them. The compound bearing 5-bromo substitution was the most potent derivative. Global physicochemical properties for compounds IVa-e and Va-h were calculated and the two most active compounds (IVa and IVb) showed similar Clog P values.

Cites

No record.

References

No record.

Cite

APA: Copy

MOKHTARI, SHAYA, MOSADDEGH, MAHMOUD, HAMZELOO MOGHADAM, MARYAM, SOLEYMANI, ZOHREH, GHAFARI, SAEIDEH, & KOBARFARD, FARZAD. (2012). SYNTHESIS AND CYTOTOXIC EVALUATION OF NOVEL 3-SUBSTITUTED DERIVATIVES OF 2-INDOLINONE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(2), 411-421. SID. https://sid.ir/paper/287946/en

Vancouver: Copy

MOKHTARI SHAYA, MOSADDEGH MAHMOUD, HAMZELOO MOGHADAM MARYAM, SOLEYMANI ZOHREH, GHAFARI SAEIDEH, KOBARFARD FARZAD. SYNTHESIS AND CYTOTOXIC EVALUATION OF NOVEL 3-SUBSTITUTED DERIVATIVES OF 2-INDOLINONE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(2):411-421. Available from: https://sid.ir/paper/287946/en

IEEE: Copy

SHAYA MOKHTARI, MAHMOUD MOSADDEGH, MARYAM HAMZELOO MOGHADAM, ZOHREH SOLEYMANI, SAEIDEH GHAFARI, and FARZAD KOBARFARD, “SYNTHESIS AND CYTOTOXIC EVALUATION OF NOVEL 3-SUBSTITUTED DERIVATIVES OF 2-INDOLINONE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 2, pp. 411–421, 2012, [Online]. Available: https://sid.ir/paper/287946/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops