FORMULATION AND EVALUATION OF TASTE MASKED MOUTH DISSOLVING TABLETS OF LEVOCETIRIZINE HYDROCHLORIDE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHARMA VIJAY; CHOPRA HIMANSU

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:2 Page(s): 457-463

Download Full-Text

View:

373

Download:

172

Cites:

Information Journal Paper

Title

FORMULATION AND EVALUATION OF TASTE MASKED MOUTH DISSOLVING TABLETS OF LEVOCETIRIZINE HYDROCHLORIDE

Author(s)

SHARMA VIJAY | CHOPRA HIMANSU | Issue Writer Certificate

Keywords

LEVOCETIRIZINE

TULSION-335

DRUG-RESIN COMPLEX

SUPERDISINTEGRANT

Abstract

Aim of this research work was to develop mouth dissolving tablet that disintegrates rapidly in mouth by using tasteless complex of LEVOCETIRIZINE and TULSION-335. Effect of different parameters such as swelling time, resin activation, drug resin ratio as well as stirring time was optimized by taste and percentage drug loading. Formulated DRC (Drug Resin Complex) was characterized by infrared spectroscopy, thermal analysis and X-ray diffraction pattern. Tablets were formulated by wet granulation with PVP as binder, Sodium Starch Glycolate (SSG) and Crospovidone as super disintegrants. In these batches optimum hardness was achieved but disintegration time was found to be very high as ³70 second, so further trials were planned by using different SUPERDISINTEGRANTs such as Croscarmellose sodium, Sodium Starch Glycolate (SSG) as well as Crospovidone by wet granulation method. Tablets formulated with 7.5% crospovidone showed comparatively low disintegration time (25 sec), wetting time (20 sec) and friability (0.60 %) than the other batches. In present study we optimized the conditions required for maximum drug loading of LEVOCETIRIZINE with TULSION-335. Among different superdisintergants, crospovidone was found suitable with DRUG-RESIN COMPLEX to get the low disintegration time, wetting time and friability of tablets.

Cites

No record.

References

No record.

Cite

APA: Copy

SHARMA, VIJAY, & CHOPRA, HIMANSU. (2012). FORMULATION AND EVALUATION OF TASTE MASKED MOUTH DISSOLVING TABLETS OF LEVOCETIRIZINE HYDROCHLORIDE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(2), 457-463. SID. https://sid.ir/paper/287967/en

Vancouver: Copy

SHARMA VIJAY, CHOPRA HIMANSU. FORMULATION AND EVALUATION OF TASTE MASKED MOUTH DISSOLVING TABLETS OF LEVOCETIRIZINE HYDROCHLORIDE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(2):457-463. Available from: https://sid.ir/paper/287967/en

IEEE: Copy

VIJAY SHARMA, and HIMANSU CHOPRA, “FORMULATION AND EVALUATION OF TASTE MASKED MOUTH DISSOLVING TABLETS OF LEVOCETIRIZINE HYDROCHLORIDE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 2, pp. 457–463, 2012, [Online]. Available: https://sid.ir/paper/287967/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops