STUDY OF ORGANIC SOLVENT TOLERANCE AND INCREASED ANTIBIOTIC RESISTANCE PROPERTIES IN E. COLI GYRA MUTANTS

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POURAHMAD JAKTAJI RAZIEH; EBADI RAYHANEH; KARIMI MARZIEH

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Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:2 Page(s): 595-600

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Information Journal Paper

Title

STUDY OF ORGANIC SOLVENT TOLERANCE AND INCREASED ANTIBIOTIC RESISTANCE PROPERTIES IN E. COLI GYRA MUTANTS

Author(s)

POURAHMAD JAKTAJI RAZIEH | EBADI RAYHANEH | KARIMI MARZIEH | Issue Writer Certificate

Keywords

GYRA MUTANTS

ORGANIC SOLVENT TOLERANCE

TETRACYCLINE RESISTANT MUTANTS

MARR MUTATION

Abstract

Ciprofloxacin is one of the most widely used antibiotics for the treatment of several infections caused by Gram-negative bacteria, like E. coli. Changes in gyrA, encoding GyrA subunit of DNA gyrase, cause the resistance to ciprofloxacin. Some ciprofloxacin resistant GYRA MUTANTS acquired constitutive expression of marRAB operon due to the gaining mutations in marR, a repressor of this operon. This leads to the expression of a multidrug resistance phenotype and high ORGANIC SOLVENT TOLERANCE. Thus, this study was aimed to provide more information on extra mechanisms of resistance in GYRA MUTANTS with different ciprofloxacin MICs. For this purpose, the tolerance of organic solvent, resistance to tetracycline and presence of possible mutation in marOR were investigated in 10 GYRA MUTANTS. Results showed that most of GYRA MUTANTS behaved like MG1655, control strain, but 3 out of 10 were slightly more resistant to tetracycline than MG1655 and had better growth on hexane. Among three mutants, two possess a mutation in marOR. In conclusion, the generation of mutation in marOR is not enough by itself to produce the multidrug resistance phenotype and complete activation of AcrAB-TolC.

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APA: Copy

POURAHMAD JAKTAJI, RAZIEH, EBADI, RAYHANEH, & KARIMI, MARZIEH. (2012). STUDY OF ORGANIC SOLVENT TOLERANCE AND INCREASED ANTIBIOTIC RESISTANCE PROPERTIES IN E. COLI GYRA MUTANTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(2), 595-600. SID. https://sid.ir/paper/287970/en

Vancouver: Copy

POURAHMAD JAKTAJI RAZIEH, EBADI RAYHANEH, KARIMI MARZIEH. STUDY OF ORGANIC SOLVENT TOLERANCE AND INCREASED ANTIBIOTIC RESISTANCE PROPERTIES IN E. COLI GYRA MUTANTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(2):595-600. Available from: https://sid.ir/paper/287970/en

IEEE: Copy

RAZIEH POURAHMAD JAKTAJI, RAYHANEH EBADI, and MARZIEH KARIMI, “STUDY OF ORGANIC SOLVENT TOLERANCE AND INCREASED ANTIBIOTIC RESISTANCE PROPERTIES IN E. COLI GYRA MUTANTS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 2, pp. 595–600, 2012, [Online]. Available: https://sid.ir/paper/287970/en

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