GRACILARIOPSIS PERSICA FROM PERSIAN GULF CONTAINS BIOACTIVE STEROLS

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SAEIDNIA SOUDABEH; PERMEH PARISA; GOHARI AHMAD REZA; MASHINCHIAN MORADI ALI

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:3 Page(s): 845-849

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Title

GRACILARIOPSIS PERSICA FROM PERSIAN GULF CONTAINS BIOACTIVE STEROLS

Author(s)

SAEIDNIA SOUDABEH | PERMEH PARISA | GOHARI AHMAD REZA | MASHINCHIAN MORADI ALI | Issue Writer Certificate

Keywords

GRACILARIOPSIS PERSICA

22-DEHYDROCHOLESTEROL

CHOLESTEROL

FUCOSTEROL

CYTOTOXICITY

Abstract

GRACILARIOPSIS PERSICA (Rhodophyta) is one of the most abundant algae, introduced newly from the Indian Ocean. In this study, the main sterols of the algae have been isolated and identified. Separation and purification of the compounds was carried out on silica gel and sephadex LH20 column chromatography (CC) and high performance liquid chromatography (HPLC) to obtain five pure compounds 1-5. Structural elucidation of the compounds was based on the data obtained from H-NMR, 13C-NMR, DEPT and Mass spectroscopy. The separated compounds from Gp. Persica were identified as 22-DEHYDROCHOLESTEROL (1), CHOLESTEROL (2), stigmasterol (3), b-sitosterol (4) and FUCOSTEROL (5) based on the spectral data compared to those reported in literatures. Most of these sterols are noteworthy for their effectiveness in decreasing the plasma CHOLESTEROL, glucose and inflammation. The results of Brine Shrimp CYTOTOXICITY Assay indicated that the ethyl acetate extract of Gp. Persica showed a high cytotoxic effect against A. salina nauplii (LC50=4 g/mL). The methanol extract was no effective but the aqueous methanol extract was moderately effective (LC50=40 mg/mL) compared to berberine hydrochloride as a positive control (LC50=26 mg/mL).

Cites

PHYTOCHEMISTRY AND ANTIOXIDANT ACTIVITY OF LALLEMANTIA IBERICA AERIAL PARTS

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APA: Copy

SAEIDNIA, SOUDABEH, PERMEH, PARISA, GOHARI, AHMAD REZA, & MASHINCHIAN MORADI, ALI. (2012). GRACILARIOPSIS PERSICA FROM PERSIAN GULF CONTAINS BIOACTIVE STEROLS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(3), 845-849. SID. https://sid.ir/paper/287993/en

Vancouver: Copy

SAEIDNIA SOUDABEH, PERMEH PARISA, GOHARI AHMAD REZA, MASHINCHIAN MORADI ALI. GRACILARIOPSIS PERSICA FROM PERSIAN GULF CONTAINS BIOACTIVE STEROLS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(3):845-849. Available from: https://sid.ir/paper/287993/en

IEEE: Copy

SOUDABEH SAEIDNIA, PARISA PERMEH, AHMAD REZA GOHARI, and ALI MASHINCHIAN MORADI, “GRACILARIOPSIS PERSICA FROM PERSIAN GULF CONTAINS BIOACTIVE STEROLS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 3, pp. 845–849, 2012, [Online]. Available: https://sid.ir/paper/287993/en

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