SYNTHESIS OF SOME NEW QUINAZOLINONE DERIVATIVES AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITIES

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KHODARAHMI GHADAM ALI; JAFARI ELHAM; HAKIMELAHI GHOLAMHOSSEIN; ABEDI DARYOUSH; RAHMANI KHAJOUEI MARZIEH; HASSANZADEH FARSHID

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Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:3 Page(s): 789-797

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Title

SYNTHESIS OF SOME NEW QUINAZOLINONE DERIVATIVES AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITIES

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Keywords

FUSED QUINAZOLINONS

DEOXYVASICINONE

BENZOXAZINONE

ANTIBACTERIAL ACTIVITY

ANTIFUNGAL ACTIVITY

Abstract

Wide range of quinazolinone biological properties including: antibacterial, anticancer, and anti-inflammatory activities encouraged us to synthesis some fused quinazolinone derivatives.Anthranilic acid was condensed with chloro acylchloride followed by dehydration to form the BENZOXAZINONE intermediate; subsequent addition of an amine provided the fused quinazolinones. DEOXYVASICINONE which was previously synthesized by a multi step complex reactions was prepared in three steps using the following procedure:LogP values of the compounds were measured using the shake flask method in octanol/water solvent system.The synthesized compounds were evaluated against six strains of bacteria (three Gram-positive and three Gram-negative) and three strains of fungi.Overall results of antimicrobial tests showed that the compounds had better bacteriostatic activity against Gram-negative bacteria. The obtained results of MBC revealed that these compounds had more significant bacteriostatic than bactericidal activities. Almost all of the screened compounds showed good activity againstC. albicans and A. niger. The obtained results of MFC indicated that these compounds had more significant fungistatic than fungicidal activities.

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APA: Copy

KHODARAHMI, GHADAM ALI, JAFARI, ELHAM, HAKIMELAHI, GHOLAMHOSSEIN, ABEDI, DARYOUSH, RAHMANI KHAJOUEI, MARZIEH, & HASSANZADEH, FARSHID. (2012). SYNTHESIS OF SOME NEW QUINAZOLINONE DERIVATIVES AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(3), 789-797. SID. https://sid.ir/paper/287994/en

Vancouver: Copy

KHODARAHMI GHADAM ALI, JAFARI ELHAM, HAKIMELAHI GHOLAMHOSSEIN, ABEDI DARYOUSH, RAHMANI KHAJOUEI MARZIEH, HASSANZADEH FARSHID. SYNTHESIS OF SOME NEW QUINAZOLINONE DERIVATIVES AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(3):789-797. Available from: https://sid.ir/paper/287994/en

IEEE: Copy

GHADAM ALI KHODARAHMI, ELHAM JAFARI, GHOLAMHOSSEIN HAKIMELAHI, DARYOUSH ABEDI, MARZIEH RAHMANI KHAJOUEI, and FARSHID HASSANZADEH, “SYNTHESIS OF SOME NEW QUINAZOLINONE DERIVATIVES AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITIES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 3, pp. 789–797, 2012, [Online]. Available: https://sid.ir/paper/287994/en

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