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Information Journal Paper

Title

ACUTE ADMINISTRATION OF NATURAL HONEY PROTECTS ISOLATED HEART IN NORMOTHERMIC ISCHEMIA

Pages

  1275-1284

Abstract

 This study intended to assess the efficacy of ACUTE ADMINISTRATION of NATURAL HONEY on cardiac ARRHYTHMIAs and INFARCT SIZE when it is used during the NORMOTHERMIC ISCHEMIA in isolated rat heart.During 30 min of regional NORMOTHERMIC ISCHEMIA followed by 120 min of reperfusion, the isolated hearts were perfused by a modified drug free Krebs-Henseleit solution (control) or the solution containing 0.125, 0.25, 0.5 and 1% of freshly prepared NATURAL HONEY (test groups), respectively. Cardiac ARRHYTHMIAs were analyzed and determined through the recorded ECGs. The INFARCT SIZE was measured using computerized planimetry package.At the ischemic phase, honey (0.25 and 0.5%) decreased the number and duration of ventricular tachycardia (VT), total number of ventricular ectopic beats (VEBs), duration and incidence of reversible ventricular fibrillation (VF) and total VF (p<0.05 for all). During the reperfusion, concentrations of 0.125, 0.25 and 0.5% lowered the number of VT (p<0.05), duration of reversible VF (p<0.01) and total number of VEBs (p<0.05). In addition, VT duration was reduced significantly with honey 0.125 and 0.25%. Moreover, the INFARCT SIZE was 45.6±3.4% in the control group, while the perfusion of honey (0.125, 0.25 and 0.5%) reduced it to 14.8±5.1 (p<0.001), 24.6±7.3 (p<0.01) and 31.4±7.3% (p<0.05), respectively.Regarding the results, it is concluded that the ACUTE ADMINISTRATION of NATURAL HONEY in NORMOTHERMIC ISCHEMIA conditions can protect the rat heart as the reduction of INFARCT SIZE and ARRHYTHMIAs. Conceivably, the antioxidant and free radical scavenging activity, the reduction of necrotized tissue and the providence of rich energy source are more important mechanisms in cardioprotective effects of NATURAL HONEY.

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    • Cite

    APA: Copy

    GHAREKHANI, AFSHIN, NAJAFI, MOSLEM, & GHAVIMI, HAMED. (2012). ACUTE ADMINISTRATION OF NATURAL HONEY PROTECTS ISOLATED HEART IN NORMOTHERMIC ISCHEMIA. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(4), 1275-1284. SID. https://sid.ir/paper/288044/en

    Vancouver: Copy

    GHAREKHANI AFSHIN, NAJAFI MOSLEM, GHAVIMI HAMED. ACUTE ADMINISTRATION OF NATURAL HONEY PROTECTS ISOLATED HEART IN NORMOTHERMIC ISCHEMIA. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(4):1275-1284. Available from: https://sid.ir/paper/288044/en

    IEEE: Copy

    AFSHIN GHAREKHANI, MOSLEM NAJAFI, and HAMED GHAVIMI, “ACUTE ADMINISTRATION OF NATURAL HONEY PROTECTS ISOLATED HEART IN NORMOTHERMIC ISCHEMIA,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 4, pp. 1275–1284, 2012, [Online]. Available: https://sid.ir/paper/288044/en

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