DEVELOPMENT OF A SIMPLE RP-HPLC-UV METHOD FOR DETERMINATION OF AZITHROMYCIN IN BULK AND PHARMACEUTICAL DOSAGE FORMS AS AN ALTERNATIVE TO THE USP METHOD

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GHARI TAYEBEH; KOBARFARD FARZAD; MORTAZAVI SEYED ALI REZA

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:SUPPLEMENT 1 Page(s): 57-63

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Title

DEVELOPMENT OF A SIMPLE RP-HPLC-UV METHOD FOR DETERMINATION OF AZITHROMYCIN IN BULK AND PHARMACEUTICAL DOSAGE FORMS AS AN ALTERNATIVE TO THE USP METHOD

Author(s)

GHARI TAYEBEH | KOBARFARD FARZAD | MORTAZAVI SEYED ALI REZA | Issue Writer Certificate

Keywords

AZITHROMYCIN

HPLC

UV DETECTION

DETERMINATION

PHARMACEUTICALS

Abstract

The present study was designed to develop a simple, validated liquid chromatographic method for the analysis of AZITHROMYCIN in bulk and pharmaceutical dosage forms using ultraviolet detector. The best stationary phase was determined as C18 column, 5 mm, 250 mm´4.6 mm. Mobile phase was optimized to obtain a fast and selective separation of the drug. Flow rate was 1.5 mL/min, Wavelength was set at 210 nm and the volume of each injection was 500 mL. An isocratic methanol/buffer mobile phase at the ratio of 90: 10 v/v gave the best separation and resolution. The proposed method was accurate, precise, sensitive, and linear over a wide range of concentration of AZITHROMYCIN. The developed method has the advantage of using UV detector compared to the USP method in which electrochemical detector has been used. The validated method was successfully applied to the DETERMINATION of AZITHROMYCIN in bulk and pharmaceutical dosage forms.

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APA: Copy

GHARI, TAYEBEH, KOBARFARD, FARZAD, & MORTAZAVI, SEYED ALI REZA. (2013). DEVELOPMENT OF A SIMPLE RP-HPLC-UV METHOD FOR DETERMINATION OF AZITHROMYCIN IN BULK AND PHARMACEUTICAL DOSAGE FORMS AS AN ALTERNATIVE TO THE USP METHOD. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(SUPPLEMENT 1), 57-63. SID. https://sid.ir/paper/288045/en

Vancouver: Copy

GHARI TAYEBEH, KOBARFARD FARZAD, MORTAZAVI SEYED ALI REZA. DEVELOPMENT OF A SIMPLE RP-HPLC-UV METHOD FOR DETERMINATION OF AZITHROMYCIN IN BULK AND PHARMACEUTICAL DOSAGE FORMS AS AN ALTERNATIVE TO THE USP METHOD. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(SUPPLEMENT 1):57-63. Available from: https://sid.ir/paper/288045/en

IEEE: Copy

TAYEBEH GHARI, FARZAD KOBARFARD, and SEYED ALI REZA MORTAZAVI, “DEVELOPMENT OF A SIMPLE RP-HPLC-UV METHOD FOR DETERMINATION OF AZITHROMYCIN IN BULK AND PHARMACEUTICAL DOSAGE FORMS AS AN ALTERNATIVE TO THE USP METHOD,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. SUPPLEMENT 1, pp. 57–63, 2013, [Online]. Available: https://sid.ir/paper/288045/en

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