ELECTROCHEMICAL SYNTHESIS OF NOVEL 1, 3-INDANDIONE DERIVATIVES AND EVALUATION OF THEIR ANTIPLATELET AGGREGATION ACTIVITIES

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AMIDI SALIMEH; KOBARFARD FARZAD; BAYANDORI MOGHADDAM ABDOLMAJID; TABIB KIMIA; SOLEYMANI ZOHREH

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:SUPPLEMENT 1 Page(s): 91-103

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Title

ELECTROCHEMICAL SYNTHESIS OF NOVEL 1, 3-INDANDIONE DERIVATIVES AND EVALUATION OF THEIR ANTIPLATELET AGGREGATION ACTIVITIES

Author(s)

Keywords

ELECTROCHEMICAL SYNTHESIS

3-INDANDIONE

PLATELET AGGREGATION INHIBITION

Abstract

Electrochemical oxidation of some selected catechol derivatives, using cyclic voltammetry, in the presence of different 2-aryl-1, 3-INDANDIONEs as nucleophiles, resulted in ELECTROCHEMICAL SYNTHESIS of new 1, 3- indandione derivatives in an undivided cell in good yield and purity. A Michael addition mechanism was proposed for the formation of the analogs based on the reaction conditions which were provided in electrochemical cell. Thein-vitro antiplatelet and anticoagulant activity of these compounds was evaluated, using arachidonic acid (AA) and adenosine diphosphate (ADP) as the platelet aggregation inducers. The results show that the incorporation of catechol ring in 1, 3-INDANDIONE nucleus leads to the emergence of antiplatelet aggregation activity in these compounds. The compounds may exert their antiaggregation activity by interfering with the arachidonic acid pathway.

Cites

EVALUATION OF ANTI-PLATELET AGGREGATION EFFECT OF SOME ALLIUM SPECIES

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APA: Copy

AMIDI, SALIMEH, KOBARFARD, FARZAD, BAYANDORI MOGHADDAM, ABDOLMAJID, TABIB, KIMIA, & SOLEYMANI, ZOHREH. (2013). ELECTROCHEMICAL SYNTHESIS OF NOVEL 1, 3-INDANDIONE DERIVATIVES AND EVALUATION OF THEIR ANTIPLATELET AGGREGATION ACTIVITIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(SUPPLEMENT 1), 91-103. SID. https://sid.ir/paper/288052/en

Vancouver: Copy

AMIDI SALIMEH, KOBARFARD FARZAD, BAYANDORI MOGHADDAM ABDOLMAJID, TABIB KIMIA, SOLEYMANI ZOHREH. ELECTROCHEMICAL SYNTHESIS OF NOVEL 1, 3-INDANDIONE DERIVATIVES AND EVALUATION OF THEIR ANTIPLATELET AGGREGATION ACTIVITIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(SUPPLEMENT 1):91-103. Available from: https://sid.ir/paper/288052/en

IEEE: Copy

SALIMEH AMIDI, FARZAD KOBARFARD, ABDOLMAJID BAYANDORI MOGHADDAM, KIMIA TABIB, and ZOHREH SOLEYMANI, “ELECTROCHEMICAL SYNTHESIS OF NOVEL 1, 3-INDANDIONE DERIVATIVES AND EVALUATION OF THEIR ANTIPLATELET AGGREGATION ACTIVITIES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. SUPPLEMENT 1, pp. 91–103, 2013, [Online]. Available: https://sid.ir/paper/288052/en

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