LONG-TERM MORPHINE-TREATED RATS ARE MORE SENSITIVE TO ANTINOCICEPTIVE EFFECT OF DICLOFENAC THAN THE MORPHINE-NAIVE RATS

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AKBARI ESMAEIL; MIRZAEI EBRAHIM; SHAHABI MAJD NAGHI

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Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:1 Page(s): 175-184

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Title

LONG-TERM MORPHINE-TREATED RATS ARE MORE SENSITIVE TO ANTINOCICEPTIVE EFFECT OF DICLOFENAC THAN THE MORPHINE-NAIVE RATS

Author(s)

AKBARI ESMAEIL | MIRZAEI EBRAHIM | SHAHABI MAJD NAGHI | Issue Writer Certificate

Keywords

DICLOFENAC SODIUM

MORPHINE-DEPENDENT RAT

FORMALIN TEST

Abstract

This study investigates the effectiveness of the antinociceptive effects of diclofenac, an NSAID, on the nociceptive behavior of morphine-treated rats on FORMALIN TEST.Rats were treated with morphine-containing drinking water for twenty one days, which induced morphine dependence. The antinociceptive effects of 8, 16, and 32 mg/kg doses of diclofenac were then evaluated and compared with distilled water in a formalin-based model of pain.Diclofenac potentiated pain suppression in MORPHINE-DEPENDENT RATs during the interphase of the FORMALIN TEST and reduced the pain score during phase II. The post-test analysis revealed that both 16 mg/kg (p<0.0001) and 32 mg/kg (p<0.0001) doses of diclofenac had a significant effect on the interphase, while 8 mg/kg (p<0.05), 16 mg/kg (p<0.05), and 32 mg/kg (p<0.01) doses of diclofenac significantly affected phase II. In contrast, the antinociceptive effects of diclofenac on morphine-naïve rats were observed during phase II only with the a 32 mg/kg dose (p<0.05).In general, these results suggest that the long-term use of morphine in rats increases their sensitivity to the antinociceptive effects of diclofenac. Furthermore, the results support the existence of a non-opioid-dependent mechanism of pain suppression during the interphase of FORMALIN TEST.

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APA: Copy

AKBARI, ESMAEIL, MIRZAEI, EBRAHIM, & SHAHABI MAJD, NAGHI. (2013). LONG-TERM MORPHINE-TREATED RATS ARE MORE SENSITIVE TO ANTINOCICEPTIVE EFFECT OF DICLOFENAC THAN THE MORPHINE-NAIVE RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(1), 175-184. SID. https://sid.ir/paper/288072/en

Vancouver: Copy

AKBARI ESMAEIL, MIRZAEI EBRAHIM, SHAHABI MAJD NAGHI. LONG-TERM MORPHINE-TREATED RATS ARE MORE SENSITIVE TO ANTINOCICEPTIVE EFFECT OF DICLOFENAC THAN THE MORPHINE-NAIVE RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(1):175-184. Available from: https://sid.ir/paper/288072/en

IEEE: Copy

ESMAEIL AKBARI, EBRAHIM MIRZAEI, and NAGHI SHAHABI MAJD, “LONG-TERM MORPHINE-TREATED RATS ARE MORE SENSITIVE TO ANTINOCICEPTIVE EFFECT OF DICLOFENAC THAN THE MORPHINE-NAIVE RATS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 1, pp. 175–184, 2013, [Online]. Available: https://sid.ir/paper/288072/en

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