PROTECTIVE EFFECTS OF VITAMIN C AND NAC ON THE TOXICITY OF RIFAMPIN ON HEPG2 CELLS

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VAHDATI MASHHADIAN NASSER; JAFARI MAHMOUD REZA; SHARGHI NASIM; SANATI TOKTAM

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:1 Page(s): 141-146

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Title

PROTECTIVE EFFECTS OF VITAMIN C AND NAC ON THE TOXICITY OF RIFAMPIN ON HEPG2 CELLS

Author(s)

VAHDATI MASHHADIAN NASSER | JAFARI MAHMOUD REZA | SHARGHI NASIM | SANATI TOKTAM | Issue Writer Certificate

Keywords

HEPG2

CELL TOXICITY

MTT ASSAY

VITAMIN C

NAC

Abstract

Rifampin, an antibiotic widely used for the treatment of mycobacterial infections, produces hepatic, renal and bone marrow toxicity in human and animals. In this study, the protective effects of VITAMIN C andn -acetylcysteine (NAC) on the toxicity of rifampin on HEPG2 cells were investigated.Human hepatoma cells (HEPG2) were cultured in 96-well M of rifampin in the presence of microplate and exposed to 10, 20, 50 and 100 VITAMIN C (0.1 mg/mL) and NAC (0.2 mg/mL). Protective effect of the two drugs against rifampin toxicity was assessed by MTT ASSAY.Results show that both VITAMIN C and NAC significantly inhibited HEPG2 cellular damagedue to rifampin, and VITAMIN C was relatively more potent than NAC. Rifampin is metabolized by the liver and its toxic metabolites are responsible for the drug›s hepatic toxicity. Based on our results, it seems that reactive metabolites are the main agents responsible for rifampin hepatotoxicity. The importance of this finding is that if VITAMIN C or NAC do not affect the antibacterial activity of rifampin, they could be used as preventive agents in rifampin users.

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APA: Copy

VAHDATI MASHHADIAN, NASSER, JAFARI, MAHMOUD REZA, SHARGHI, NASIM, & SANATI, TOKTAM. (2013). PROTECTIVE EFFECTS OF VITAMIN C AND NAC ON THE TOXICITY OF RIFAMPIN ON HEPG2 CELLS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(1), 141-146. SID. https://sid.ir/paper/288080/en

Vancouver: Copy

VAHDATI MASHHADIAN NASSER, JAFARI MAHMOUD REZA, SHARGHI NASIM, SANATI TOKTAM. PROTECTIVE EFFECTS OF VITAMIN C AND NAC ON THE TOXICITY OF RIFAMPIN ON HEPG2 CELLS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(1):141-146. Available from: https://sid.ir/paper/288080/en

IEEE: Copy

NASSER VAHDATI MASHHADIAN, MAHMOUD REZA JAFARI, NASIM SHARGHI, and TOKTAM SANATI, “PROTECTIVE EFFECTS OF VITAMIN C AND NAC ON THE TOXICITY OF RIFAMPIN ON HEPG2 CELLS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 1, pp. 141–146, 2013, [Online]. Available: https://sid.ir/paper/288080/en

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