ACUTE AND SUBACUTE TOXICITY OF SAFRANAL, A CONSTITUENT OF SAFFRON, IN MICE AND RATS

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HOSSEINZADEH HOSSEIN; SADEGHI SHAKIB SAIED; KHADEM SAMENI ABBAS; TAGHIABADI ELAHE

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Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:1 Page(s): 93-99

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Information Journal Paper

Title

ACUTE AND SUBACUTE TOXICITY OF SAFRANAL, A CONSTITUENT OF SAFFRON, IN MICE AND RATS

Author(s)

HOSSEINZADEH HOSSEIN | SADEGHI SHAKIB SAIED | KHADEM SAMENI ABBAS | TAGHIABADI ELAHE | Issue Writer Certificate

Keywords

SAFRANAL

CROCUS SATIVUS

SAFFRON

ACUTE TOXICITY

SUBACUTE TOXICITY

Abstract

The acute and sub-acute toxicity of SAFRANAL were studied in rat and mice within 2 and 21 days after exposure, respectively. For SUBACUTE TOXICITY, changes in weight as well as biochemical, hematological and pathological parameters were studied. The intra peritoneal LD50 values of SAFRANAL were 1.48 mL/kg in male mice, 1.88 mL/kg in female mice and 1.50 mL/kg in male rats. Oral LD50 values were 21.42 mL/kg in male mice, 11.42 mL/kg in female mice and 5.53 mL/kg in male rats. For SUBACUTE TOXICITY, SAFRANAL was administered orally to male rats once daily for 21 days. In hematological tests, a significant decrease in RBC counts, hematocrit, hemoglobin and platelets were observed. SAFRANAL decreased cholesterol, triglyceride and alkalin phosphatase. Lactate dehydrogenase and serum urea nitrogen were increased by SAFRANAL. Histological studies indicated that SAFRANAL did not have any toxic effect on the heart, liver and spleen. However, pathological changes were seen in the kidney and lung. According to LD50 values, SAFRANAL was low-toxic in acute intra peritoneal route and practically non-toxic in acute oral administration in both mice and rats. In SUBACUTE TOXICITY, SAFRANAL changed some hematological and biochemical parameters.

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APA: Copy

HOSSEINZADEH, HOSSEIN, SADEGHI SHAKIB, SAIED, KHADEM SAMENI, ABBAS, & TAGHIABADI, ELAHE. (2013). ACUTE AND SUBACUTE TOXICITY OF SAFRANAL, A CONSTITUENT OF SAFFRON, IN MICE AND RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(1), 93-99. SID. https://sid.ir/paper/288099/en

Vancouver: Copy

HOSSEINZADEH HOSSEIN, SADEGHI SHAKIB SAIED, KHADEM SAMENI ABBAS, TAGHIABADI ELAHE. ACUTE AND SUBACUTE TOXICITY OF SAFRANAL, A CONSTITUENT OF SAFFRON, IN MICE AND RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(1):93-99. Available from: https://sid.ir/paper/288099/en

IEEE: Copy

HOSSEIN HOSSEINZADEH, SAIED SADEGHI SHAKIB, ABBAS KHADEM SAMENI, and ELAHE TAGHIABADI, “ACUTE AND SUBACUTE TOXICITY OF SAFRANAL, A CONSTITUENT OF SAFFRON, IN MICE AND RATS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 1, pp. 93–99, 2013, [Online]. Available: https://sid.ir/paper/288099/en

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