مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

STUDY OF THE HEPATOPROTECTIVE ACTIVITY OF METHANOLIC EXTRACT OF FEIJOA SELLOWIANAFRUITS AGAINST MDMA USING THE ISOLATED RAT LIVER PERFUSION SYSTEM

Pages

  85-91

Abstract

 liver injury induced by viruses, chemicals and drugs can be protected by different medicinal plants.FEIJOA SELLOWIANA (Myrtaceae) is an evergreen bush native to southern areas of South America, as well as Iran where the fruits are very popular. Feijoa has shown a potent antimicrobial effect. Morever, the antioxidant activity of total Feijoa extract has also been reported. MDMA or ecstasy is a ring-substituted amphetamine derivative which has been abused as a widespread recreational drug by the young generation. Liver is a target organ for MDMA toxicity. In fact, this sense MDMA is metabolized by cytochromes P4502D, 2B and 3Aand reactive metabolites are readily oxidized to the corresponding o-qiuinones and reactive oxygen species (ROS). This study investigated whether methanilicFEIJOA SELLOWIANA fruits can produce biochemical changes using the Isolated Rat LIVER PERFUSION (IRLP) system. The, the liver was perfused with different concentrations of the extract (10, 20, 40, 50, 100 mg/kg), added to the buffer and perfused within 2 h. During the perfusion we tried to find out the antioxidant activity or liver protective effect of Feijoa, by determinining amino-transferases activities (SGOT and SGPT) and glutathione reductase (GSH) level in comparison with the positive and negative controls. Subsequently, sections of liver tissue were examined for any histopathological changes. The results revealed that the activities of SGOT and SGPT were seriously decreased and GSH level was significantly increased by the Feijoa extract. Overall, necrosis in the liver parenchyma was decreased. These findings revealed that FEIJOA SELLOWIANA is an effective hepatoprotective plant.

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    • Cite

    APA: Copy

    KARAMI, MOHAMMAD, SAEIDNIA, SOUDABEH, & NOSRATI, ANAHITA. (2013). STUDY OF THE HEPATOPROTECTIVE ACTIVITY OF METHANOLIC EXTRACT OF FEIJOA SELLOWIANAFRUITS AGAINST MDMA USING THE ISOLATED RAT LIVER PERFUSION SYSTEM. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(1), 85-91. SID. https://sid.ir/paper/288103/en

    Vancouver: Copy

    KARAMI MOHAMMAD, SAEIDNIA SOUDABEH, NOSRATI ANAHITA. STUDY OF THE HEPATOPROTECTIVE ACTIVITY OF METHANOLIC EXTRACT OF FEIJOA SELLOWIANAFRUITS AGAINST MDMA USING THE ISOLATED RAT LIVER PERFUSION SYSTEM. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(1):85-91. Available from: https://sid.ir/paper/288103/en

    IEEE: Copy

    MOHAMMAD KARAMI, SOUDABEH SAEIDNIA, and ANAHITA NOSRATI, “STUDY OF THE HEPATOPROTECTIVE ACTIVITY OF METHANOLIC EXTRACT OF FEIJOA SELLOWIANAFRUITS AGAINST MDMA USING THE ISOLATED RAT LIVER PERFUSION SYSTEM,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 1, pp. 85–91, 2013, [Online]. Available: https://sid.ir/paper/288103/en

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