PROPRANOLOL PREVENTS OSTEOPOROSIS AND UP-REGULATES LEPTIN IN OVARIECTOMIZED RATS

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ZHANG XINGGUANG; LV XIAOFENG; ZHANG YANQI; JIAO XIUMIN; CHEN BIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:3 Page(s): 557-562

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Title

PROPRANOLOL PREVENTS OSTEOPOROSIS AND UP-REGULATES LEPTIN IN OVARIECTOMIZED RATS

Author(s)

Keywords

PROPRANOLOL

OSTEOPOROSIS

LEPTIN

OVARIECTOMIZED RAT

Abstract

Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. LEPTIN has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on LEPTIN signaling has not been clearly understood. In the present study, we studied the effect of PROPRANOLOL on ovariectomy-induced OSTEOPOROSIS of rat. The results showed PROPRANOLOL could increase the bone mass of OVARIECTOMIZED RAT. PROPRANOLOL could also up-regulate the level of peripheral LEPTIN and the level of LEPTIN receptor expression in OVARIECTOMIZED RAT hypothalamus. Our results indicate the effect of PROPRANOLOL on ovariectomy-induced OSTEOPOROSIS may be exerted, at least partly, through the regulation of LEPTIN signaling and there may be an interaction between the SNS and LEPTIN on the regulation of bone metabolism.

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APA: Copy

ZHANG, XINGGUANG, LV, XIAOFENG, ZHANG, YANQI, JIAO, XIUMIN, & CHEN, BIN. (2013). PROPRANOLOL PREVENTS OSTEOPOROSIS AND UP-REGULATES LEPTIN IN OVARIECTOMIZED RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(3), 557-562. SID. https://sid.ir/paper/288118/en

Vancouver: Copy

ZHANG XINGGUANG, LV XIAOFENG, ZHANG YANQI, JIAO XIUMIN, CHEN BIN. PROPRANOLOL PREVENTS OSTEOPOROSIS AND UP-REGULATES LEPTIN IN OVARIECTOMIZED RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(3):557-562. Available from: https://sid.ir/paper/288118/en

IEEE: Copy

XINGGUANG ZHANG, XIAOFENG LV, YANQI ZHANG, XIUMIN JIAO, and BIN CHEN, “PROPRANOLOL PREVENTS OSTEOPOROSIS AND UP-REGULATES LEPTIN IN OVARIECTOMIZED RATS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 3, pp. 557–562, 2013, [Online]. Available: https://sid.ir/paper/288118/en

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