مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

272
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

284
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

EVALUATION OF THE ANTIBACTERIAL ACTIVITY OF PATCHOULI OIL

Pages

  307-316

Abstract

 In the present study, the antimicrobial tests of PATCHOULI OIL were studied by using MOLECULAR DOCKING technology and antimicrobial test in vitro. Five biological macromolecule enzymes, required by the bacteria in the process of biosynthesis were selected as target molecules. Five antibiotics benzylpenicillin, sulfadiazine, trimethoprim, rifampicin and ciprofloxacin, which are generally acknowledged as antibacterial drugs, were selected as reference compounds. The 3 three-dimensional (3D) structures of the 5 reference compounds and 26 compounds from PATCHOULI OIL were established by using surflex-dock software (8.1). And the 3D structures of five biological macromolecule enzymes derived from Protein Data Bank (PDB). MOLECULAR DOCKING was carried out between the 31 chemical compounds (ligands) and the 5 enzymes (receptors) by using surflex-dock function. Furthermore, the antibacterial effects of 31 chemical compounds were investigated by the SCORING FUNCTION after MOLECULAR DOCKING was completed. By comparing the scoring result of 26 compounds in PATCHOULI OIL with 5 compared components, we inferred antibacterial activity in about 26 compounds in PATCHOULI OIL. On the other hand, six frequently-used pathogenic bacteria were selected for antimicrobial test in vitro, PATCHOULI OIL and its two major compounds: (-)-patchouli alcohol and pogostone, which their contents exceeded 60% in PATCHOULI OIL samples, were selected antibacterial agents. Minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) were also determined. MOLECULAR DOCKING technology and antimicrobial test in vitro proved that PATCHOULI OIL had strong antimicrobial effects. Particularly, pogostone and (-)-patchouli alcohol have potent antimicrobial activity.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    YANG, XIAN, ZHANG, XUE, YANGA, SHUI PING, & LIU, WEI QI. (2013). EVALUATION OF THE ANTIBACTERIAL ACTIVITY OF PATCHOULI OIL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(3), 307-316. SID. https://sid.ir/paper/288134/en

    Vancouver: Copy

    YANG XIAN, ZHANG XUE, YANGA SHUI PING, LIU WEI QI. EVALUATION OF THE ANTIBACTERIAL ACTIVITY OF PATCHOULI OIL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(3):307-316. Available from: https://sid.ir/paper/288134/en

    IEEE: Copy

    XIAN YANG, XUE ZHANG, SHUI PING YANGA, and WEI QI LIU, “EVALUATION OF THE ANTIBACTERIAL ACTIVITY OF PATCHOULI OIL,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 3, pp. 307–316, 2013, [Online]. Available: https://sid.ir/paper/288134/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button