PRECIPITATION REACTION OF SDS AND POTASSIUM SALTS IN FLOCCULATION OF A MICRONIZED MEGESTROL ACETATE SUSPENSION

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HEJAZI SEYED MEHDI; ERFAN MOHAMMAD; MORTAZAVI SEYED ALIREZA

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:3 Page(s): 239-246

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Information Journal Paper

Title

PRECIPITATION REACTION OF SDS AND POTASSIUM SALTS IN FLOCCULATION OF A MICRONIZED MEGESTROL ACETATE SUSPENSION

Author(s)

HEJAZI SEYED MEHDI | ERFAN MOHAMMAD | MORTAZAVI SEYED ALIREZA | Issue Writer Certificate

Keywords

KCL-SDS PRECIPITATION REACTION

FLOCCULATION

HPMC-SDS INTERACTION

MEGESTROL ACETATE

SUSPENSIONS

Abstract

In this work attempts were made to evaluate K+-SDS and hydrocolloid polymer-SDS interactions in FLOCCULATION of MEGESTROL ACETATE dispersions to enhance their stability as a part of suspension formulation. Different dispersions of micronized MEGESTROL ACETATE and SDS were prepared. KCl and KH2PO4 and their corresponding sodium salts were added to the dispersions and the preparations were evaluated using general physicochemical and stability tests including appearance, sedimentation volume, sedimentation rate and redispersibility. Addition of polyols and hydrocolloid polymers to the SDS containing dispersions was also investigated for possible instabilities. SDS deflocculated the initial MEGESTROL ACETATE dispersions. The use of potassium salts unlike the sodium salts flocculated the dispersion particles due to precipitation reaction of potassium ions and the adsorbed SDS. Additionally the uncharged hydrocolloid polymers MC and HPMC in contrast to the ionic polymers xanthan gum and NaCMC showed incompatibility due to their interaction with SDS. K+- SDS interactions have proved useful in protein and DNA analysis studies and we found this precipitation reaction to be applicable in FLOCCULATION of pharmaceutical SUSPENSIONS containing SDS.

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APA: Copy

HEJAZI, SEYED MEHDI, ERFAN, MOHAMMAD, & MORTAZAVI, SEYED ALIREZA. (2013). PRECIPITATION REACTION OF SDS AND POTASSIUM SALTS IN FLOCCULATION OF A MICRONIZED MEGESTROL ACETATE SUSPENSION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(3), 239-246. SID. https://sid.ir/paper/288137/en

Vancouver: Copy

HEJAZI SEYED MEHDI, ERFAN MOHAMMAD, MORTAZAVI SEYED ALIREZA. PRECIPITATION REACTION OF SDS AND POTASSIUM SALTS IN FLOCCULATION OF A MICRONIZED MEGESTROL ACETATE SUSPENSION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(3):239-246. Available from: https://sid.ir/paper/288137/en

IEEE: Copy

SEYED MEHDI HEJAZI, MOHAMMAD ERFAN, and SEYED ALIREZA MORTAZAVI, “PRECIPITATION REACTION OF SDS AND POTASSIUM SALTS IN FLOCCULATION OF A MICRONIZED MEGESTROL ACETATE SUSPENSION,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 3, pp. 239–246, 2013, [Online]. Available: https://sid.ir/paper/288137/en

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