مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

SYNTHESIS AND ANTIMYCOBACTERIAL ACTIVITY OF SYMMETRIC THIOCARBOHYDRAZONE DERIVATIVES AGAINST MYCOBACTERIUM BOVIS BCG KAMALEDDIN

Pages

  331-346

Abstract

 In this work, we reported the synthesis and evaluation of antimycobacterial and ANTIFUNGAL activity of a series of THIOCARBOHYDRAZONE derivatives which are THIACETAZONE congeners. The target compounds were synthesized in superior yields by reacting thiocarbohydrazide with different aromatic aldehydes and methyl ketones. Compounds 8, 19 and 25 were found to be the most potent derivatives, exhibiting acceptable activity against MYCOBACTERIUM BOVIS BCG compared to THIACETAZONE and ethambutol as reference substances. Compounds 8,15 and 25 exhibited the highest activity against Candida albicans. The most active compounds had a completely different aromatic ring system with various electronic, steric and lipophilic natures. This is understandable in light of the fact that carbohydrazone derivatives must undergo a metabolic activation step before exerting their anti-TB activity and different SAR rules govern each one of these two processes.

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    APA: Copy

    TEHRANI, MOHAMMAD EBRAHIM, KOBARFARD, FARZAD, AZERANG, PARISA, MEHRAVAR, MARYAM, SOLEIMANI, ZOHREH, GHAVAMI, GHAZALEH, & SARDARI, SOROUSH. (2013). SYNTHESIS AND ANTIMYCOBACTERIAL ACTIVITY OF SYMMETRIC THIOCARBOHYDRAZONE DERIVATIVES AGAINST MYCOBACTERIUM BOVIS BCG KAMALEDDIN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(2), 331-346. SID. https://sid.ir/paper/288152/en

    Vancouver: Copy

    TEHRANI MOHAMMAD EBRAHIM, KOBARFARD FARZAD, AZERANG PARISA, MEHRAVAR MARYAM, SOLEIMANI ZOHREH, GHAVAMI GHAZALEH, SARDARI SOROUSH. SYNTHESIS AND ANTIMYCOBACTERIAL ACTIVITY OF SYMMETRIC THIOCARBOHYDRAZONE DERIVATIVES AGAINST MYCOBACTERIUM BOVIS BCG KAMALEDDIN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(2):331-346. Available from: https://sid.ir/paper/288152/en

    IEEE: Copy

    MOHAMMAD EBRAHIM TEHRANI, FARZAD KOBARFARD, PARISA AZERANG, MARYAM MEHRAVAR, ZOHREH SOLEIMANI, GHAZALEH GHAVAMI, and SOROUSH SARDARI, “SYNTHESIS AND ANTIMYCOBACTERIAL ACTIVITY OF SYMMETRIC THIOCARBOHYDRAZONE DERIVATIVES AGAINST MYCOBACTERIUM BOVIS BCG KAMALEDDIN,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 2, pp. 331–346, 2013, [Online]. Available: https://sid.ir/paper/288152/en

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